BindingDB PrimarySearch

BDBM50240189 CHEMBL4069119::US9962398, Compound MST-140

SMILES: NS(=O)(=O)c1ccc(NC(=O)Nc2ccc(F)c(F)c2F)cc1

InChI Key: InChIKey=UHHFDMJXDRDKSQ-UHFFFAOYSA-N

Data: 8 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50240189
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Carbonic anhydrase 12 (Homo sapiens (Human))	BDBM50240189 (CHEMBL4069119 \| US9962398, Compound MST-140) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	6.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibitory activity against dog gastric proton-pump enzyme H+/K+ ATPase				Bioorg Med Chem 25: 2569-2576 (2017) Article DOI: 10.1016/j.bmc.2017.03.027 BindingDB Entry DOI: 10.7270/Q22F7QKP
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 12 (Homo sapiens (Human))	BDBM50240189 (CHEMBL4069119 \| US9962398, Compound MST-140) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	6.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington at Seattle					Assay Description CA INHIBITION DATA WITH UREIDOSUBSTITUTED SULFONAMIDES				J Med Chem 52: 1864-72 (2009) BindingDB Entry DOI: 10.7270/Q2Q242KS
University of Washington at Seattle					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM50240189 (CHEMBL4069119 \| US9962398, Compound MST-140) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	9.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington at Seattle					Assay Description CA INHIBITION DATA WITH UREIDOSUBSTITUTED SULFONAMIDES				J Med Chem 52: 1864-72 (2009) BindingDB Entry DOI: 10.7270/Q2Q242KS
University of Washington at Seattle					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM50240189 (CHEMBL4069119 \| US9962398, Compound MST-140) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	9.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibitory activity of gastric proton-pump enzyme H+/K+ ATPase was determined at 50 uM				Bioorg Med Chem 25: 2569-2576 (2017) Article DOI: 10.1016/j.bmc.2017.03.027 BindingDB Entry DOI: 10.7270/Q22F7QKP
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50240189 (CHEMBL4069119 \| US9962398, Compound MST-140) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	335	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibitory activity against dog gastric proton-pump enzyme H+/K+ ATPase				Bioorg Med Chem 25: 2569-2576 (2017) Article DOI: 10.1016/j.bmc.2017.03.027 BindingDB Entry DOI: 10.7270/Q22F7QKP
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50240189 (CHEMBL4069119 \| US9962398, Compound MST-140) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	335	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington at Seattle					Assay Description CA INHIBITION DATA WITH UREIDOSUBSTITUTED SULFONAMIDES				J Med Chem 52: 1864-72 (2009) BindingDB Entry DOI: 10.7270/Q2Q242KS
University of Washington at Seattle					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM50240189 (CHEMBL4069119 \| US9962398, Compound MST-140) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	484	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington at Seattle					Assay Description CA INHIBITION DATA WITH UREIDOSUBSTITUTED SULFONAMIDES				J Med Chem 52: 1864-72 (2009) BindingDB Entry DOI: 10.7270/Q2Q242KS
University of Washington at Seattle					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM50240189 (CHEMBL4069119 \| US9962398, Compound MST-140) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	484	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stoppe...				Bioorg Med Chem 25: 2569-2576 (2017) Article DOI: 10.1016/j.bmc.2017.03.027 BindingDB Entry DOI: 10.7270/Q22F7QKP
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair