BDBM50240419 (E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one::6-shogaol::CHEMBL25948::[(E)-1-(4-hydroxy-3-methoxyphenyl)-dec-4-en-3-one]::[6]-shogaol::trans-6-shogaol

SMILES: CCCCCC=CC(=O)CCc1ccc(O)c(OC)c1

InChI Key: InChIKey=OQWKEEOHDMUXEO-UHFFFAOYSA-N

Data: 1 KI  7 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50240419   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50240419 ((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one ...) Show SMILES CCCCCC=CC(=O)CCc1ccc(O)c(OC)c1 |w:5.4| Show InChI InChI=1S/C17H24O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h7-8,10,12-13,19H,3-6,9,11H2,1-2H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Department of Chemistry and Applied Biosciences Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counting				Bioorg Med Chem 18: 3345-51 (2010) Article DOI: 10.1016/j.bmc.2010.02.062 BindingDB Entry DOI: 10.7270/Q2RN381W
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Rattus norvegicus)	BDBM50240419 ((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one ...) Show SMILES CCCCCC=CC(=O)CCc1ccc(O)c(OC)c1 |w:5.4| Show InChI InChI=1S/C17H24O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h7-8,10,12-13,19H,3-6,9,11H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.67E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza Universit£ di Roma Curated by ChEMBL					Assay Description Antagonist activity at rat TRPA1 ion channel expressed in HEK293 cells assessed as inhibition of AITC-induced calcium influx incubated for 5 mins pri...				Bioorg Med Chem Lett 22: 1674-7 (2012) Article DOI: 10.1016/j.bmcl.2011.12.113 BindingDB Entry DOI: 10.7270/Q20002JM
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50240419 ((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one ...) Show SMILES CCCCCC=CC(=O)CCc1ccc(O)c(OC)c1 |w:5.4| Show InChI InChI=1S/C17H24O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h7-8,10,12-13,19H,3-6,9,11H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	320	n/a	n/a	n/a	n/a
Sapienza Universit£ di Roma Curated by ChEMBL					Assay Description Agonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry				Bioorg Med Chem Lett 22: 1674-7 (2012) Article DOI: 10.1016/j.bmcl.2011.12.113 BindingDB Entry DOI: 10.7270/Q20002JM
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50240419 ((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one ...) Show SMILES CCCCCC=CC(=O)CCc1ccc(O)c(OC)c1 |w:5.4| Show InChI InChI=1S/C17H24O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h7-8,10,12-13,19H,3-6,9,11H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.77E+4	n/a	n/a	n/a	n/a	n/a	n/a
Toyama Medical and Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human CYP3A4 by radiometric assay				J Nat Prod 67: 1079-83 (2004) Article DOI: 10.1021/np030556a BindingDB Entry DOI: 10.7270/Q2668CZP
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (Human))	BDBM50240419 ((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one ...) Show SMILES CCCCCC=CC(=O)CCc1ccc(O)c(OC)c1 |w:5.4| Show InChI InChI=1S/C17H24O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h7-8,10,12-13,19H,3-6,9,11H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.46E+4	n/a	n/a	n/a	n/a	n/a	n/a
Mansoura University Curated by ChEMBL					Assay Description Inhibition of recombinant C-terminal His-tagged human LTA4H epoxide hydrolase activity expressed in Escherichia coli assessed as reduction in LTB4 pr...				Bioorg Med Chem 25: 1277-1285 (2017) Article DOI: 10.1016/j.bmc.2016.12.048 BindingDB Entry DOI: 10.7270/Q2SJ1NMK
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50240419 ((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one ...) Show SMILES CCCCCC=CC(=O)CCc1ccc(O)c(OC)c1 |w:5.4| Show InChI InChI=1S/C17H24O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h7-8,10,12-13,19H,3-6,9,11H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Advanced Industrial Science and Technology (AIST) Curated by ChEMBL					Assay Description Inhibition of 5LOX				Bioorg Med Chem 16: 10332-7 (2008) Article DOI: 10.1016/j.bmc.2008.10.038 BindingDB Entry DOI: 10.7270/Q24M94C2
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Rattus norvegicus)	BDBM50240419 ((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one ...) Show SMILES CCCCCC=CC(=O)CCc1ccc(O)c(OC)c1 |w:5.4| Show InChI InChI=1S/C17H24O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h7-8,10,12-13,19H,3-6,9,11H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a
Sapienza Universit£ di Roma Curated by ChEMBL					Assay Description Agonist activity at rat TRPA1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry				Bioorg Med Chem Lett 22: 1674-7 (2012) Article DOI: 10.1016/j.bmcl.2011.12.113 BindingDB Entry DOI: 10.7270/Q20002JM
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (Human))	BDBM50240419 ((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one ...) Show SMILES CCCCCC=CC(=O)CCc1ccc(O)c(OC)c1 |w:5.4| Show InChI InChI=1S/C17H24O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h7-8,10,12-13,19H,3-6,9,11H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
Mansoura University Curated by ChEMBL					Assay Description Inhibition of recombinant C-terminal His-tagged human LTA4H epoxide hydrolase activity expressed in Escherichia coli assessed as reduction in LTB4 pr...				Bioorg Med Chem 25: 1277-1285 (2017) Article DOI: 10.1016/j.bmc.2016.12.048 BindingDB Entry DOI: 10.7270/Q2SJ1NMK
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50240419 ((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one ...) Show SMILES CCCCCC=CC(=O)CCc1ccc(O)c(OC)c1 |w:5.4| Show InChI InChI=1S/C17H24O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h7-8,10,12-13,19H,3-6,9,11H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza Universit£ di Roma Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium influx incubated for 5 m...				Bioorg Med Chem Lett 22: 1674-7 (2012) Article DOI: 10.1016/j.bmcl.2011.12.113 BindingDB Entry DOI: 10.7270/Q20002JM
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50240419 ((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one ...) Show SMILES CCCCCC=CC(=O)CCc1ccc(O)c(OC)c1 |w:5.4| Show InChI InChI=1S/C17H24O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h7-8,10,12-13,19H,3-6,9,11H2,1-2H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Toyama Medical and Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human CYP2D6 by radiometric assay				J Nat Prod 67: 1079-83 (2004) Article DOI: 10.1021/np030556a BindingDB Entry DOI: 10.7270/Q2668CZP
					More data for this Ligand-Target Pair