BDBM50240669 Acetic acid (S)-5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl ester::CHEMBL87992::ESLICARBAZEPINE
SMILES: CC(=O)O[C@H]1Cc2ccccc2N(C(N)=O)c2ccccc12
InChI Key: InChIKey=QIALRBLEEWJACW-INIZCTEOSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type I I alpha subunit (Rattus norvegicus) | BDBM50240669 (Acetic acid (S)-5-carbamoyl-10,11-dihydro-5H-diben...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <1.38E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
BIAL Curated by ChEMBL | Assay Description Displacement of [3H]BTX from voltage-gated sodium channel of rat cortical synaptosomes | J Med Chem 42: 2582-7 (1999) Article DOI: 10.1021/jm980627g BindingDB Entry DOI: 10.7270/Q2QN69GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 4 (Homo sapiens (Human)) | BDBM50240669 (Acetic acid (S)-5-carbamoyl-10,11-dihydro-5H-diben...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn Curated by ChEMBL | Assay Description Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate... | Bioorg Med Chem 22: 1077-88 (2014) Article DOI: 10.1016/j.bmc.2013.12.035 BindingDB Entry DOI: 10.7270/Q21R6S09 | |||||||||||
More data for this Ligand-Target Pair |