Found 13 hits for monomerid = 50240850 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cytochrome P450 2A6
(Homo sapiens (Human)) | BDBM50240850
((2-Isothiocyanato-ethyl)-benzene | CHEMBL151649 | ...)Show InChI InChI=1S/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description Mixed inhibition of CYP2A6 (unknown origin) |
Drug Metab Dispos 40: 1797-802 (2012)
Article DOI: 10.1124/dmd.112.045161 BindingDB Entry DOI: 10.7270/Q2BK1F3P |
More data for this Ligand-Target Pair | |
Cytochrome P450 2A13
(Homo sapiens (Human)) | BDBM50240850
((2-Isothiocyanato-ethyl)-benzene | CHEMBL151649 | ...)Show InChI InChI=1S/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description Mixed inhibition of CYP2A13 (unknown origin) |
Drug Metab Dispos 40: 1797-802 (2012)
Article DOI: 10.1124/dmd.112.045161 BindingDB Entry DOI: 10.7270/Q2BK1F3P |
More data for this Ligand-Target Pair | |
Cytochrome P450 2E1
(Homo sapiens (Human)) | BDBM50240850
((2-Isothiocyanato-ethyl)-benzene | CHEMBL151649 | ...)Show InChI InChI=1S/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
| PubMed
| 9.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Mechanism based inhibition of human cytochrome P450 2E1 |
Curr Drug Metab 6: 413-54 (2005)
BindingDB Entry DOI: 10.7270/Q2VQ33X3 |
More data for this Ligand-Target Pair | |
Cytochrome P450 2E1
(Homo sapiens (Human)) | BDBM50240850
((2-Isothiocyanato-ethyl)-benzene | CHEMBL151649 | ...)Show InChI InChI=1S/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School
Curated by ChEMBL
| Assay Description Inhibition of human CYP2E1 expressed in Escherichia coli MV1304 assessed as reduction in 7-EFC O-de-ethylation activity by spectrofluorometry based d... |
Drug Metab Dispos 41: 858-69 (2013)
Article DOI: 10.1124/dmd.112.050609 BindingDB Entry DOI: 10.7270/Q2V69MBS |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50240850
((2-Isothiocyanato-ethyl)-benzene | CHEMBL151649 | ...)Show InChI InChI=1S/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | n/a | 18 | n/a | n/a | n/a | n/a |
University of Shizuoka
Curated by ChEMBL
| Assay Description Activation of human TRPV1 expressed in TREx-HEK cells by Fluo-4 AM dye-based Ca2+ imaging assay |
J Nat Prod 78: 1937-41 (2015)
Article DOI: 10.1021/acs.jnatprod.5b00272 BindingDB Entry DOI: 10.7270/Q27946FQ |
More data for this Ligand-Target Pair | |
Replicase polyprotein 1ab
(2019-nCoV) | BDBM50240850
((2-Isothiocyanato-ethyl)-benzene | CHEMBL151649 | ...)Show InChI InChI=1S/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Patents
| | n/a | n/a | 1.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor (MIF)
(Homo sapiens (Human)) | BDBM50240850
((2-Isothiocyanato-ethyl)-benzene | CHEMBL151649 | ...)Show InChI InChI=1S/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2 | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Otago
Curated by ChEMBL
| Assay Description Inhibition of human recombinant macrophage migration inhibitory factor tautomerase activity expressed in Escherichia coli DH5alpha using L-dopachrome... |
Eur J Med Chem 93: 501-10 (2015)
Article DOI: 10.1016/j.ejmech.2015.02.012 BindingDB Entry DOI: 10.7270/Q26Q1ZZ7 |
More data for this Ligand-Target Pair | |
Cytochrome P450 2A6
(Homo sapiens (Human)) | BDBM50240850
((2-Isothiocyanato-ethyl)-benzene | CHEMBL151649 | ...)Show InChI InChI=1S/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description Binding affinity to CYP2A6 (unknown origin) assessed as type 1 interaction as increase in absorbance 379 to 387 nm and decrease in 414 to 420 nm |
Drug Metab Dispos 40: 1797-802 (2012)
Article DOI: 10.1124/dmd.112.045161 BindingDB Entry DOI: 10.7270/Q2BK1F3P |
More data for this Ligand-Target Pair | |
Cytochrome P450 2A13
(Homo sapiens (Human)) | BDBM50240850
((2-Isothiocyanato-ethyl)-benzene | CHEMBL151649 | ...)Show InChI InChI=1S/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description Binding affinity to CYP2A13 (unknown origin) assessed as type 1 interaction as increase in absorbance 379 to 387 nm and decrease in 414 to 420 nm |
Drug Metab Dispos 40: 1797-802 (2012)
Article DOI: 10.1124/dmd.112.045161 BindingDB Entry DOI: 10.7270/Q2BK1F3P |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Homo sapiens (Human)) | BDBM50240850
((2-Isothiocyanato-ethyl)-benzene | CHEMBL151649 | ...)Show InChI InChI=1S/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a |
Ferrara University
Curated by ChEMBL
| Assay Description Activation of TRPA1 channel |
J Med Chem 53: 5085-107 (2010)
Article DOI: 10.1021/jm100062h BindingDB Entry DOI: 10.7270/Q2416Z02 |
More data for this Ligand-Target Pair | |
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha
(Homo sapiens (Human)) | BDBM50240850
((2-Isothiocyanato-ethyl)-benzene | CHEMBL151649 | ...)Show InChI InChI=1S/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 7.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Southampton Faculty of Medicine
Curated by ChEMBL
| Assay Description Inhibition of Serine/threonine-protein kinase mTOR complex 1-mediated HIF1alpha RNA translation in human MCF7 cells pretreated for 1 hr prior to meta... |
J Nat Prod 75: 1051-7 (2012)
Article DOI: 10.1021/np300049b BindingDB Entry DOI: 10.7270/Q2F47S1N |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Homo sapiens (Human)) | BDBM50240850
((2-Isothiocyanato-ethyl)-benzene | CHEMBL151649 | ...)Show InChI InChI=1S/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | n/a | 37 | n/a | n/a | n/a | n/a |
University of Shizuoka
Curated by ChEMBL
| Assay Description Activation of human TRPA1 expressed in TREx-HEK cells by Fluo-4 AM dye-based Ca2+ imaging assay |
J Nat Prod 78: 1937-41 (2015)
Article DOI: 10.1021/acs.jnatprod.5b00272 BindingDB Entry DOI: 10.7270/Q27946FQ |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor (MIF)
(Homo sapiens (Human)) | BDBM50240850
((2-Isothiocyanato-ethyl)-benzene | CHEMBL151649 | ...)Show InChI InChI=1S/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2 | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Otago
Curated by ChEMBL
| Assay Description Inhibition of macrophage migration inhibitory factor tautomerase activity in human Jurkat T cells using L-dopachrome methyl ester as substrate incuba... |
Eur J Med Chem 93: 501-10 (2015)
Article DOI: 10.1016/j.ejmech.2015.02.012 BindingDB Entry DOI: 10.7270/Q26Q1ZZ7 |
More data for this Ligand-Target Pair | |