BDBM86248 CAS_364-98-7::DIAZOXIDE::NSC_3019::diazoxide

SMILES: CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1

InChI Key: InChIKey=GDLBFKVLRPITMI-UHFFFAOYSA-N

Data: 2 KI  4 IC50  1 Kd  6 EC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 86248   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium channel (ATP modulatory) (GUINEA PIG)	BDBM86248 (CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide) Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 |t:1| Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)	Reactome pathway UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Patents	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by PDSP Ki Database									Mol Pharmacol 64: 143-53 (2003) Article DOI: 10.1124/mol.64.1.143 BindingDB Entry DOI: 10.7270/Q22B8WMJ
					More data for this Ligand-Target Pair
Potassium channel (ATP modulatory) (GUINEA PIG)	BDBM86248 (CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide) Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 |t:1| Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)	Reactome pathway UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Patents	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by PDSP Ki Database									Mol Pharmacol 64: 143-53 (2003) Article DOI: 10.1124/mol.64.1.143 BindingDB Entry DOI: 10.7270/Q22B8WMJ
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1 (Homo sapiens (Human))	BDBM86248 (CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide) Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 |t:1| Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.94E+5	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells in presence of 2 mM ATP				J Med Chem 49: 4127-39 (2006) Article DOI: 10.1021/jm060042j BindingDB Entry DOI: 10.7270/Q2B27TWN
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1 (Homo sapiens (Human))	BDBM86248 (CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide) Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 |t:1| Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a
University of Perugia Curated by ChEMBL					Assay Description Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as activation of K+ currents				J Med Chem 50: 2117-26 (2007) Article DOI: 10.1021/jm061440p BindingDB Entry DOI: 10.7270/Q2PK0FTT
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1 (Homo sapiens (Human))	BDBM86248 (CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide) Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 |t:1| Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Patents	PubMed	n/a	n/a	n/a	n/a	8.80E+3	n/a	n/a	n/a	n/a
GlaxoSmithKline Research & Development Curated by ChEMBL					Assay Description Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes				Bioorg Med Chem Lett 14: 813-6 (2004) BindingDB Entry DOI: 10.7270/Q29P312R
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1 (Homo sapiens (Human))	BDBM86248 (CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide) Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 |t:1| Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Patents	PubMed	n/a	n/a	1.98E+5	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk Research and Development Curated by ChEMBL					Assay Description Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low ...				J Med Chem 45: 4171-87 (2002) BindingDB Entry DOI: 10.7270/Q2SF2VGM
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1 (Homo sapiens (Human))	BDBM86248 (CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide) Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 |t:1| Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Patents	PubMed	n/a	n/a	n/a	n/a	8.80E+3	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Inhibition of Beta-cell KATP channel				Bioorg Med Chem Lett 12: 2977-80 (2002) BindingDB Entry DOI: 10.7270/Q20V8C4M
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1 (Homo sapiens (Human))	BDBM86248 (CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide) Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 |t:1| Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	3.30E+4	n/a	n/a	n/a	n/a
University of Perugia Curated by ChEMBL					Assay Description Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarization				J Med Chem 50: 2117-26 (2007) Article DOI: 10.1021/jm061440p BindingDB Entry DOI: 10.7270/Q2PK0FTT
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM86248 (CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide) Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 |t:1| Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	n/a	2.30E+5	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Binding affinity to NAMPT (2 to 491) (unknown origin) by surface plasmon resonance analysis				J Med Chem 57: 770-92 (2014) Article DOI: 10.1021/jm4015108 BindingDB Entry DOI: 10.7270/Q2BC412B
					More data for this Ligand-Target Pair				3D Structure (crystal)
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1 (Homo sapiens (Human))	BDBM86248 (CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide) Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 |t:1| Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	2.35E+4	n/a	n/a	n/a	n/a
Universite de Liege Curated by ChEMBL					Assay Description Activation of human recombinant SUR1/Kir6.2 channel expressed in HEK293 cells assessed as increase in ionic current by whole cell patch clamp assay				J Med Chem 53: 147-54 (2010) Article DOI: 10.1021/jm9010093 BindingDB Entry DOI: 10.7270/Q2C82B7T
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1 (Homo sapiens (Human))	BDBM86248 (CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide) Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 |t:1| Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	7.40E+5	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells				J Med Chem 49: 4127-39 (2006) Article DOI: 10.1021/jm060042j BindingDB Entry DOI: 10.7270/Q2B27TWN
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1 (Homo sapiens (Human))	BDBM86248 (CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide) Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 |t:1| Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	3.30E+4	n/a	n/a	n/a	n/a
Novo Nordisk Research and Development Curated by ChEMBL					Assay Description Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channels				J Med Chem 49: 4127-39 (2006) Article DOI: 10.1021/jm060042j BindingDB Entry DOI: 10.7270/Q2B27TWN
					More data for this Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1 (Homo sapiens (Human))	BDBM86248 (CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide) Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 |t:1| Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Patents	PubMed	n/a	n/a	7.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk Research and Development Curated by ChEMBL					Assay Description Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...				J Med Chem 45: 4171-87 (2002) BindingDB Entry DOI: 10.7270/Q2SF2VGM
					More data for this Ligand-Target Pair