BDBM50241254 2-(benzyl-hydroxycarbamoylmethyl-amino)-N-[2-(4-sulfamoyl-phenyl)-ethyl]-acetamide::CHEMBL234737::N-Benzyl-N-{[2-(4-sulfamoylphenyl)ethylcarbamoyl]methyl}-aminoacetohydroxamic Acid
SMILES: NS(=O)(=O)c1ccc(CCNC(=O)CN(CC(=O)NO)Cc2ccccc2)cc1
InChI Key: InChIKey=IIOCRGOBAHXAAI-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Carbonic anhydrase 9 (Homo sapiens (Human)) | BDBM50241254 (2-(benzyl-hydroxycarbamoylmethyl-amino)-N-[2-(4-su...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Superior Técnico Curated by ChEMBL | Assay Description Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydrase assay | J Med Chem 51: 7968-79 (2008) Article DOI: 10.1021/jm800964f BindingDB Entry DOI: 10.7270/Q2XK8FDN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM50241254 (2-(benzyl-hydroxycarbamoylmethyl-amino)-N-[2-(4-su...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 63 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Superior Técnico Curated by ChEMBL | Assay Description Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay | J Med Chem 51: 7968-79 (2008) Article DOI: 10.1021/jm800964f BindingDB Entry DOI: 10.7270/Q2XK8FDN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM50241254 (2-(benzyl-hydroxycarbamoylmethyl-amino)-N-[2-(4-su...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 2.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Superior Técnico Curated by ChEMBL | Assay Description Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay | J Med Chem 51: 7968-79 (2008) Article DOI: 10.1021/jm800964f BindingDB Entry DOI: 10.7270/Q2XK8FDN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pseudolysin (Pseudomonas aeruginosa) | BDBM50241254 (2-(benzyl-hydroxycarbamoylmethyl-amino)-N-[2-(4-su...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
UiT - The Arctic University of Norway Curated by ChEMBL | Assay Description Inhibition of Pseudomonas aeruginosa pseudolysin using Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide as substrate after 15 mins | Eur J Med Chem 89: 340-8 (2015) Article DOI: 10.1016/j.ejmech.2014.10.009 BindingDB Entry DOI: 10.7270/Q21Z47DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-9 (Homo sapiens (Human)) | BDBM50241254 (2-(benzyl-hydroxycarbamoylmethyl-amino)-N-[2-(4-su...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Superior Técnico Curated by ChEMBL | Assay Description Inhibition of MMP9 | J Med Chem 51: 7968-79 (2008) Article DOI: 10.1021/jm800964f BindingDB Entry DOI: 10.7270/Q2XK8FDN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-14 (MMP14) (Homo sapiens (Human)) | BDBM50241254 (2-(benzyl-hydroxycarbamoylmethyl-amino)-N-[2-(4-su...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Superior Técnico Curated by ChEMBL | Assay Description Inhibition of MMP14 | J Med Chem 51: 7968-79 (2008) Article DOI: 10.1021/jm800964f BindingDB Entry DOI: 10.7270/Q2XK8FDN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM50241254 (2-(benzyl-hydroxycarbamoylmethyl-amino)-N-[2-(4-su...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Superior Técnico Curated by ChEMBL | Assay Description Inhibition of human recombinant MMP2 transfected in mouse melanoma cells | J Med Chem 51: 7968-79 (2008) Article DOI: 10.1021/jm800964f BindingDB Entry DOI: 10.7270/Q2XK8FDN | |||||||||||
More data for this Ligand-Target Pair |