BindingDB PrimarySearch

BDBM50241294 CHEMBL240954::SL-0101::kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside::kaempferol-3-O-(3,4-di-O-acetyl-alpha-L-rhamnopyranoside)

SMILES: C[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@H](OC(C)=O)[C@H]1OC(C)=O

InChI Key: InChIKey=POZDUGKSCAGWQI-IGKKHSBFSA-N

Data: 7 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50241294
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Ribosomal protein S6 kinase alpha-3 (Homo sapiens (Human))	BDBM50241294 (CHEMBL240954 \| SL-0101 \| kaempferol 3-O-(3'',4''-d...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of RSK2 (unknown origin) assessed as phosphorylation by Western lightning enhanced chemiluminescent reagent/HRP activity assay				ACS Med Chem Lett 6: 95-9 (2015) Article DOI: 10.1021/ml5004525 BindingDB Entry DOI: 10.7270/Q2RR20V0
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50241294 (CHEMBL240954 \| SL-0101 \| kaempferol 3-O-(3'',4''-d...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.06E+4	n/a	n/a	n/a	n/a	n/a	n/a
Toyama Medical and Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human CYP3A4 by radiometric assay				J Nat Prod 67: 1079-83 (2004) Article DOI: 10.1021/np030556a BindingDB Entry DOI: 10.7270/Q2668CZP
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50241294 (CHEMBL240954 \| SL-0101 \| kaempferol 3-O-(3'',4''-d...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.05E+4	n/a	n/a	n/a	n/a	n/a	n/a
Toyama Medical and Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human CYP2D6 by radiometric assay				J Nat Prod 67: 1079-83 (2004) Article DOI: 10.1021/np030556a BindingDB Entry DOI: 10.7270/Q2668CZP
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3 (Homo sapiens (Human))	BDBM50241294 (CHEMBL240954 \| SL-0101 \| kaempferol 3-O-(3'',4''-d...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	583	n/a	n/a	n/a	n/a	n/a	n/a
University of Virginia Curated by ChEMBL					Assay Description Inhibition of His-tagged RSK2 expressed in Sf9 cells using ERalpha-Ser167 RLASTND as substrate after 120 mins by chemiluminescence assay				Bioorg Med Chem Lett 22: 3244-7 (2012) Article DOI: 10.1016/j.bmcl.2012.03.033 BindingDB Entry DOI: 10.7270/Q2QN67S5
University of Virginia Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Ribosomal protein S6 kinase alpha-3 (Homo sapiens (Human))	BDBM50241294 (CHEMBL240954 \| SL-0101 \| kaempferol 3-O-(3'',4''-d...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of GST-fused RSK2 (unknown origin) after 10 to 45 mins by immunoblotting analysis				Bioorg Med Chem 21: 1724-34 (2013) Article DOI: 10.1016/j.bmc.2013.01.047 BindingDB Entry DOI: 10.7270/Q2GQ704N
					More data for this Ligand-Target Pair				3D Structure (docked)
Ribosomal protein S6 kinase alpha-3 (Homo sapiens (Human))	BDBM50241294 (CHEMBL240954 \| SL-0101 \| kaempferol 3-O-(3'',4''-d...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	990	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of recombinant RSK2 (unknown origin) expressed in baculovirus infected Sf9 cells assessed as decrease in substrate phosphorylation using u...				ACS Med Chem Lett 4: 175-179 (2012) Article DOI: 10.1021/ml300298v BindingDB Entry DOI: 10.7270/Q2668FHP
Vanderbilt University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Ribosomal protein S6 kinase alpha-3 (Homo sapiens (Human))	BDBM50241294 (CHEMBL240954 \| SL-0101 \| kaempferol 3-O-(3'',4''-d...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
NPO-International Laboratory of Biochemistry Curated by ChEMBL					Assay Description Inhibition of his-tagged active RSK2 (unknown origin) expressed in Sf9 cells after 10 to 45 mins by ELISA				Eur J Med Chem 86: 103-12 (2014) Article DOI: 10.1016/j.ejmech.2014.08.011 BindingDB Entry DOI: 10.7270/Q2MG7R51
					More data for this Ligand-Target Pair				3D Structure (docked)