BindingDB PrimarySearch

BDBM50241408 (2S)-liquiritigenin::7-HYDROXY-2-(4-HYDROXY-PHENYL)-CHROMAN-4-ONE::CHEMBL252642::LIQUIRTIGENIN::Liquiritigenin

SMILES: Oc1ccc(cc1)[C@@H]1CC(=O)c2ccc(O)cc2O1

InChI Key: InChIKey=FURUXTVZLHCCNA-AWEZNQCLSA-N

Data: 10 IC50

PDB links: 3 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50241408
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Xanthine dehydrogenase (Bos taurus (Bovine))	BDBM50241408 ((2S)-liquiritigenin \| 7-HYDROXY-2-(4-HYDROXY-PHENY...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.13E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of cow milk xanthine oxidase				J Nat Prod 51: 345-348 (1988) Article DOI: 10.1021/np50056a030 BindingDB Entry DOI: 10.7270/Q2DJ5FNN
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM50241408 ((2S)-liquiritigenin \| 7-HYDROXY-2-(4-HYDROXY-PHENY...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Chosun University Curated by ChEMBL					Assay Description Inhibition of human recombinant PTP1B assessed as p-nitorphenol production after 30 mins				Bioorg Med Chem 19: 3378-83 (2011) Article DOI: 10.1016/j.bmc.2011.04.037 BindingDB Entry DOI: 10.7270/Q2DF6RKT
Chosun University Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 19A1 (Homo sapiens (Human))	BDBM50241408 ((2S)-liquiritigenin \| 7-HYDROXY-2-(4-HYDROXY-PHENY...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
UPRES EA 4021 Biomol�cules et Th�rapies anti-tumorales Curated by ChEMBL					Assay Description Inhibition of human aromatase in placental microsomes				Bioorg Med Chem 16: 1474-80 (2008) Article DOI: 10.1016/j.bmc.2007.10.057 BindingDB Entry DOI: 10.7270/Q2DR2WCC
					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM50241408 ((2S)-liquiritigenin \| 7-HYDROXY-2-(4-HYDROXY-PHENY...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute Curated by ChEMBL					Assay Description Inhibition of recombinant human PTP1B assessed as hydrolysis of p-nitrophenyl phosphate after 30 mins				Bioorg Med Chem Lett 19: 5155-7 (2009) Article DOI: 10.1016/j.bmcl.2009.07.054 BindingDB Entry DOI: 10.7270/Q24X58R7
Institute Curated by ChEMBL					More data for this Ligand-Target Pair
VHL/Tyrosine-protein kinase Yes (Homo sapiens (Human))	BDBM50241408 ((2S)-liquiritigenin \| 7-HYDROXY-2-(4-HYDROXY-PHENY...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	1.13E+4	n/a	n/a	n/a	n/a	n/a	n/a
West China Hospital of Sichuan University Curated by ChEMBL					Assay Description Inhibition of YES (unknown origin)				Eur J Med Chem 166: 186-196 (2019)
					More data for this Ligand-Target Pair
Cytochrome P450 19A1 (Homo sapiens (Human))	BDBM50241408 ((2S)-liquiritigenin \| 7-HYDROXY-2-(4-HYDROXY-PHENY...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
King's College London Curated by ChEMBL					Assay Description Inhibition of human aromatase by fluorometric assay				Bioorg Med Chem 16: 8466-70 (2008) Article DOI: 10.1016/j.bmc.2008.08.034 BindingDB Entry DOI: 10.7270/Q2CV4JN9
King's College London Curated by ChEMBL					More data for this Ligand-Target Pair
Neuraminidase (Influenza A virus)	BDBM50241408 ((2S)-liquiritigenin \| 7-HYDROXY-2-(4-HYDROXY-PHENY...) Show SMILES Show InChI	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Innsbruck Curated by ChEMBL					Assay Description Inhibition of Influenza A virus (A/Puerto Rico/8/1934(H1N1)) neuraminidase by chemiluminescence based assay				J Nat Prod 77: 563-70 (2014) Article DOI: 10.1021/np400817j BindingDB Entry DOI: 10.7270/Q23J3GZJ
University of Innsbruck Curated by ChEMBL					More data for this Ligand-Target Pair
Neuraminidase (Influenza A virus)	BDBM50241408 ((2S)-liquiritigenin \| 7-HYDROXY-2-(4-HYDROXY-PHENY...) Show SMILES Show InChI	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	8.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Innsbruck Curated by ChEMBL					Assay Description Inhibition of oseltamivir-resistant Influenza A virus H1N1 B/55/08 neuraminidase by chemiluminescence based assay				J Nat Prod 77: 563-70 (2014) Article DOI: 10.1021/np400817j BindingDB Entry DOI: 10.7270/Q23J3GZJ
University of Innsbruck Curated by ChEMBL					More data for this Ligand-Target Pair
Proteasome subunit beta type-1/beta type-5 (Homo sapiens (Human))	BDBM50241408 ((2S)-liquiritigenin \| 7-HYDROXY-2-(4-HYDROXY-PHENY...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Agricultural and Food Biotechnology Curated by ChEMBL					Assay Description Inhibition of chymotrypsin-like activity of purified human erythrocyte 20S proteasome assessed as decrease in AMC hydrolysis using Suc-LLVY-AMC as su...				Eur J Med Chem 167: 291-311 (2019) Article DOI: 10.1016/j.ejmech.2019.01.044
					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM50241408 ((2S)-liquiritigenin \| 7-HYDROXY-2-(4-HYDROXY-PHENY...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Bioscience and Biotechnology Curated by ChEMBL					Assay Description Inhibition of human recombinant PTP1B				J Nat Prod 69: 1572-6 (2006) Article DOI: 10.1021/np0601861 BindingDB Entry DOI: 10.7270/Q2B8591J
					More data for this Ligand-Target Pair