BDBM50241622 CHEMBL4074577
SMILES: OC(=O)[C@H](Cc1ccccc1)NC(=O)CC(c1ccccc1)c1ccccc1
InChI Key: InChIKey=OKPOWHJBMXCHGA-QFIPXVFZSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MDM2-MDMX (Homo sapiens (Human)) | BDBM50241622 (CHEMBL4074577) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Napoli Federico II Curated by ChEMBL | Assay Description Inhibition of MDM2 in human U87MG cells assessed as reduction in MDM2 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic as... | J Med Chem 60: 8115-8130 (2017) Article DOI: 10.1021/acs.jmedchem.7b00912 BindingDB Entry DOI: 10.7270/Q2348NJ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
p53-Binding Protein HDMX (Homo sapiens (Human)) | BDBM50241622 (CHEMBL4074577) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Napoli Federico II Curated by ChEMBL | Assay Description Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ... | J Med Chem 60: 8115-8130 (2017) Article DOI: 10.1021/acs.jmedchem.7b00912 BindingDB Entry DOI: 10.7270/Q2348NJ0 | |||||||||||
More data for this Ligand-Target Pair |