BDBM50241719 CHEMBL4101977
SMILES: Fc1cccc(Cl)c1CNc1nc(n[nH]1)-c1cccc(NC(=O)C=C)c1
InChI Key: InChIKey=YFVRNHCFDWIILZ-UHFFFAOYSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM50241719 (CHEMBL4101977) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Biological Sciences, Beijing Curated by ChEMBL | Assay Description Inhibition of ADP-induced platelet aggregation in human platelet-rich plasma | J Med Chem 60: 8552-8564 (2017) Article DOI: 10.1021/acs.jmedchem.7b01075 BindingDB Entry DOI: 10.7270/Q25X2C34 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase TEC (Homo sapiens (Human)) | BDBM50241719 (CHEMBL4101977) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 306 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Biological Sciences, Beijing Curated by ChEMBL | Assay Description Inhibition of human TEC using poly[Glu:Tyr] as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition by filter binding method | J Med Chem 60: 8552-8564 (2017) Article DOI: 10.1021/acs.jmedchem.7b01075 BindingDB Entry DOI: 10.7270/Q25X2C34 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM50241719 (CHEMBL4101977) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Biological Sciences, Beijing Curated by ChEMBL | Assay Description Inhibition of ADP-induced platelet aggregation in human platelet-rich plasma | J Med Chem 60: 8552-8564 (2017) Article DOI: 10.1021/acs.jmedchem.7b01075 BindingDB Entry DOI: 10.7270/Q25X2C34 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM50241719 (CHEMBL4101977) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Biological Sciences, Beijing Curated by ChEMBL | Assay Description The compound was tested for the inhibition of fibrinogen receptor | J Med Chem 60: 8552-8564 (2017) Article DOI: 10.1021/acs.jmedchem.7b01075 BindingDB Entry DOI: 10.7270/Q25X2C34 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM50241719 (CHEMBL4101977) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Biological Sciences, Beijing Curated by ChEMBL | Assay Description Inhibition of ADP-induced platelet aggregation in human platelet-rich plasma | J Med Chem 60: 8552-8564 (2017) Article DOI: 10.1021/acs.jmedchem.7b01075 BindingDB Entry DOI: 10.7270/Q25X2C34 | |||||||||||
More data for this Ligand-Target Pair |