BindingDB PrimarySearch

BDBM50242276 CHEMBL486626::Sophoricoside

SMILES: OC[C@H]1O[C@@H](Oc2ccc(cc2)-c2coc3cc(O)cc(O)c3c2=O)[C@H](O)[C@@H](O)[C@@H]1O

InChI Key: InChIKey=ISQRJFLLIDGZEP-CMWLGVBASA-N

Data: 12 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50242276
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Interleukin-5 (Mus musculus)	BDBM50242276 (CHEMBL486626 \| Sophoricoside) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.06E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chungnam National University Curated by ChEMBL					Assay Description Inhibition of mouse IL5-mediated mouse Y16 cell proliferation after 48 hrs by WST1 assay				Bioorg Med Chem 23: 2498-504 (2015) Article DOI: 10.1016/j.bmc.2015.03.045 BindingDB Entry DOI: 10.7270/Q25D8TJF
Chungnam National University Curated by ChEMBL					More data for this Ligand-Target Pair
Interleukin-5 (Mus musculus)	BDBM50242276 (CHEMBL486626 \| Sophoricoside) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.06E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chungnam National University Curated by ChEMBL					Assay Description Inhibition interleukin-5 in mouse Y16 cells after 48 hrs by WST-1 assay				Bioorg Med Chem 21: 2543-50 (2013) Article DOI: 10.1016/j.bmc.2013.02.037 BindingDB Entry DOI: 10.7270/Q2RR20MV
Chungnam National University Curated by ChEMBL					More data for this Ligand-Target Pair
Interleukin-5 (Mus musculus)	BDBM50242276 (CHEMBL486626 \| Sophoricoside) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.06E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chungnam National University Curated by ChEMBL					Assay Description Inhibition of IL-5 in mouse pro-B Y16 cells after 48 hrs by WST1 assay				Eur J Med Chem 59: 31-8 (2013) Article DOI: 10.1016/j.ejmech.2012.11.007 BindingDB Entry DOI: 10.7270/Q2PV6MP4
Chungnam National University Curated by ChEMBL					More data for this Ligand-Target Pair
Interleukin-5 (Mus musculus)	BDBM50242276 (CHEMBL486626 \| Sophoricoside) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chungnam National University Curated by ChEMBL					Assay Description Inhibition of IL5-mediated proliferation of mouse Y16 cells by WST1 assay				Bioorg Med Chem 18: 4441-5 (2010) Article DOI: 10.1016/j.bmc.2010.04.075 BindingDB Entry DOI: 10.7270/Q2H41SDX
Chungnam National University Curated by ChEMBL					More data for this Ligand-Target Pair
Interleukin-5 (Mus musculus)	BDBM50242276 (CHEMBL486626 \| Sophoricoside) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.06E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chungnam National University Curated by ChEMBL					Assay Description Inhibition of IL-5 in mouse Y16 cells after 48 hrs by WST1 assay				Bioorg Med Chem 20: 5757-62 (2012) Article DOI: 10.1016/j.bmc.2012.08.006 BindingDB Entry DOI: 10.7270/Q2PG1SSV
Chungnam National University Curated by ChEMBL					More data for this Ligand-Target Pair
Interleukin-5 receptor subunit alpha (Mus musculus)	BDBM50242276 (CHEMBL486626 \| Sophoricoside) Show SMILES Show InChI	MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.06E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chungnam National University Curated by ChEMBL					Assay Description Inhibition of IL-5 receptor in mouse pro-B Y16 cells assessed as decrease in mIL-5 dependent cell proliferation after 48 hrs in presence of 3 units/m...				Eur J Med Chem 181: (2019) Article DOI: 10.1016/j.ejmech.2019.111574
Chungnam National University Curated by ChEMBL					More data for this Ligand-Target Pair
Interleukin-5 (Mus musculus)	BDBM50242276 (CHEMBL486626 \| Sophoricoside) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.06E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chungnam National University Curated by ChEMBL					Assay Description Inhibition of interleukin-5 in mouse Y16 cells				Bioorg Med Chem 18: 4625-9 (2011) Article DOI: 10.1016/j.bmc.2010.05.028 BindingDB Entry DOI: 10.7270/Q2B8593F
Chungnam National University Curated by ChEMBL					More data for this Ligand-Target Pair
Interleukin-5 (Mus musculus)	BDBM50242276 (CHEMBL486626 \| Sophoricoside) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.06E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chungnam National University Curated by ChEMBL					Assay Description Inhibition of mouse IL-5-induced cell proliferation in mouse Y16 cells after 48 hrs by WST-1 assay relative to control				Eur J Med Chem 139: 290-304 (2017) Article DOI: 10.1016/j.ejmech.2017.07.069 BindingDB Entry DOI: 10.7270/Q2B27XSJ
Chungnam National University Curated by ChEMBL					More data for this Ligand-Target Pair
Neuraminidase (Influenza A virus)	BDBM50242276 (CHEMBL486626 \| Sophoricoside) Show SMILES Show InChI	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Peking Union Medical College Curated by ChEMBL					Assay Description Inhibition of Influenza A Jinan/15/90 H3N2 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay				Bioorg Med Chem 16: 7141-7 (2008) Article DOI: 10.1016/j.bmc.2008.06.049 BindingDB Entry DOI: 10.7270/Q2R2145D
Peking Union Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Neuraminidase (Influenza A virus)	BDBM50242276 (CHEMBL486626 \| Sophoricoside) Show SMILES Show InChI	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Peking Union Medical College Curated by ChEMBL					Assay Description Inhibition of Influenza A PR/8/34 H1N1 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay				Bioorg Med Chem 16: 7141-7 (2008) Article DOI: 10.1016/j.bmc.2008.06.049 BindingDB Entry DOI: 10.7270/Q2R2145D
Peking Union Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Neuraminidase (Influenza A virus)	BDBM50242276 (CHEMBL486626 \| Sophoricoside) Show SMILES Show InChI	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Peking Union Medical College Curated by ChEMBL					Assay Description Inhibition of Influenza A Jiangsu/10/2003 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay				Bioorg Med Chem 16: 7141-7 (2008) Article DOI: 10.1016/j.bmc.2008.06.049 BindingDB Entry DOI: 10.7270/Q2R2145D
Peking Union Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Interleukin-5 (Mus musculus)	BDBM50242276 (CHEMBL486626 \| Sophoricoside) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chungnam National University Curated by ChEMBL					Assay Description Inhibition of interleukin-5 in mouse Y16 cells				Bioorg Med Chem 18: 4625-9 (2011) Article DOI: 10.1016/j.bmc.2010.05.028 BindingDB Entry DOI: 10.7270/Q2B8593F
Chungnam National University Curated by ChEMBL					More data for this Ligand-Target Pair