BDBM50243109 5-(2-m-tolylethynyl)pyrimidine::5-(m-tolylethynyl)pyrimidine::CHEMBL508497
SMILES: Cc1cccc(c1)C#Cc1cncnc1
InChI Key: InChIKey=WDWDORGIXVCIQC-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor (Rattus norvegicus (Rat)) | BDBM50243109 (5-(2-m-tolylethynyl)pyrimidine | 5-(m-tolylethynyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium fluorescence | Bioorg Med Chem Lett 18: 4098-101 (2008) Article DOI: 10.1016/j.bmcl.2008.05.091 BindingDB Entry DOI: 10.7270/Q2W66KJ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50243109 (5-(2-m-tolylethynyl)pyrimidine | 5-(m-tolylethynyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulation activity at mGlu5 receptor | J Med Chem 55: 1445-64 (2012) Article DOI: 10.1021/jm201139r BindingDB Entry DOI: 10.7270/Q25D8SWH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor (Rattus norvegicus (Rat)) | BDBM50243109 (5-(2-m-tolylethynyl)pyrimidine | 5-(m-tolylethynyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Negative allosteric modulator activity at rat mGluR5 receptor expressed in HEK293A cells | Bioorg Med Chem Lett 21: 2711-4 (2011) Article DOI: 10.1016/j.bmcl.2010.11.119 BindingDB Entry DOI: 10.7270/Q21C1X6Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor (Rattus norvegicus (Rat)) | BDBM50243109 (5-(2-m-tolylethynyl)pyrimidine | 5-(m-tolylethynyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in HEK293 cells assessed as inhibition of glutamate-induced response | J Med Chem 52: 4103-6 (2009) Article DOI: 10.1021/jm900654c BindingDB Entry DOI: 10.7270/Q2PZ58RJ | |||||||||||
More data for this Ligand-Target Pair |