BDBM50243595 (S)-N-Cyclohexyl-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-Nethylbenzamide::CHEMBL461292
SMILES: CCN(C1CCCCC1)C(=O)c1ccc(cc1)[C@](C)(O)C(F)(F)F
InChI Key: InChIKey=WLWHNXMTVCKXGI-KRWDZBQOSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50243595 ((S)-N-Cyclohexyl-4-(1,1,1-trifluoro-2-hydroxypropa...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human cloned 11beta-HSD1 by scintillation proximity assay | J Med Chem 51: 3953-60 (2008) Article DOI: 10.1021/jm800310g BindingDB Entry DOI: 10.7270/Q2P84CSZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50243595 ((S)-N-Cyclohexyl-4-(1,1,1-trifluoro-2-hydroxypropa...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells in presence of 3% human serum albumin | J Med Chem 51: 3953-60 (2008) Article DOI: 10.1021/jm800310g BindingDB Entry DOI: 10.7270/Q2P84CSZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50243595 ((S)-N-Cyclohexyl-4-(1,1,1-trifluoro-2-hydroxypropa...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells | J Med Chem 51: 3953-60 (2008) Article DOI: 10.1021/jm800310g BindingDB Entry DOI: 10.7270/Q2P84CSZ | |||||||||||
More data for this Ligand-Target Pair |