BDBM50243674 ((3aR,6aR)-6-(4-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,3a,4,6a-tetrahydrocyclopenta[c]pyrrol-2(1H)-yl)(tetrahydro-2H-pyran-4-yl)methanone::CHEMBL471555
SMILES: C[C@@H]1CCCN1CCc1ccc(cc1)C1=CC[C@H]2CN(C[C@@H]12)C(=O)C1CCOCC1
InChI Key: InChIKey=KTVGKRKFCUTGRP-HFRGRHLUSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histamine H3 receptor (Rattus norvegicus (rat)) | BDBM50243674 (((3aR,6aR)-6-(4-(2-((R)-2-methylpyrrolidin-1-yl)et...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane | Bioorg Med Chem Lett 18: 4133-6 (2008) Article DOI: 10.1016/j.bmcl.2008.05.086 BindingDB Entry DOI: 10.7270/Q2C82942 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Homo sapiens (Human)) | BDBM50243674 (((3aR,6aR)-6-(4-(2-((R)-2-methylpyrrolidin-1-yl)et...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Antagonist activity at human histamine H3 receptor expressed in CHOK1 cells by [3H]R(-)-alpha-methylhistamine displacement assay | Bioorg Med Chem Lett 18: 4133-6 (2008) Article DOI: 10.1016/j.bmcl.2008.05.086 BindingDB Entry DOI: 10.7270/Q2C82942 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Homo sapiens (Human)) | BDBM50243674 (((3aR,6aR)-6-(4-(2-((R)-2-methylpyrrolidin-1-yl)et...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Inverse agonist activity at human H3 receptor expressed in CHOK1 cells by GTPgammaS binding assay | Bioorg Med Chem Lett 18: 4133-6 (2008) Article DOI: 10.1016/j.bmcl.2008.05.086 BindingDB Entry DOI: 10.7270/Q2C82942 | |||||||||||
More data for this Ligand-Target Pair |