BDBM50243879 5-Hydroxy-4-(1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1,5-dihydro-2H-pyrrole-2-one::CHEMBL505253

SMILES: COc1cc(cc(OC)c1OC)C1=C(C(O)NC1=O)c1c[nH]c2ccccc12

InChI Key: InChIKey=IINDUQOQNFCDNN-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50243879   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM50243879 (5-Hydroxy-4-(1H-indol-3-yl)-3-(3,4,5-trimethoxyphe...) Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(O)NC1=O)c1c[nH]c2ccccc12 |t:13| Show InChI InChI=1S/C21H20N2O5/c1-26-15-8-11(9-16(27-2)19(15)28-3)17-18(21(25)23-20(17)24)13-10-22-14-7-5-4-6-12(13)14/h4-10,21-22,25H,1-3H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls University Curated by ChEMBL					Assay Description Inhibition of human recombinant VEGFR3				J Med Chem 51: 3814-24 (2008) Article DOI: 10.1021/jm8001185 BindingDB Entry DOI: 10.7270/Q2057FQS
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50243879 (5-Hydroxy-4-(1H-indol-3-yl)-3-(3,4,5-trimethoxyphe...) Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(O)NC1=O)c1c[nH]c2ccccc12 |t:13| Show InChI InChI=1S/C21H20N2O5/c1-26-15-8-11(9-16(27-2)19(15)28-3)17-18(21(25)23-20(17)24)13-10-22-14-7-5-4-6-12(13)14/h4-10,21-22,25H,1-3H3,(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls University Curated by ChEMBL					Assay Description Inhibition of human recombinant FLT3				J Med Chem 51: 3814-24 (2008) Article DOI: 10.1021/jm8001185 BindingDB Entry DOI: 10.7270/Q2057FQS
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50243879 (5-Hydroxy-4-(1H-indol-3-yl)-3-(3,4,5-trimethoxyphe...) Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(O)NC1=O)c1c[nH]c2ccccc12 |t:13| Show InChI InChI=1S/C21H20N2O5/c1-26-15-8-11(9-16(27-2)19(15)28-3)17-18(21(25)23-20(17)24)13-10-22-14-7-5-4-6-12(13)14/h4-10,21-22,25H,1-3H3,(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls University Curated by ChEMBL					Assay Description Inhibition of human recombinant VEGFR2				J Med Chem 51: 3814-24 (2008) Article DOI: 10.1021/jm8001185 BindingDB Entry DOI: 10.7270/Q2057FQS
					More data for this Ligand-Target Pair