Found 5 hits for monomerid = 50243906 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM50243906
(CHEMBL4063642)Show SMILES CN([C@@H]1C[C@@H](C1)NS(=O)(=O)N(C)C1CC1)c1ncnc2[nH]ccc12 |r,wD:2.1,4.6,(5.8,-11.92,;7.14,-12.68,;8.47,-11.91,;8.86,-10.41,;10.35,-10.81,;9.96,-12.3,;11.68,-10.03,;13.01,-10.8,;13.77,-12.13,;12.24,-12.12,;14.35,-10.03,;15.68,-10.8,;14.35,-8.49,;15.13,-7.16,;13.59,-7.16,;7.14,-14.22,;5.81,-15,;5.81,-16.54,;7.15,-17.31,;8.49,-16.53,;9.96,-17,;10.86,-15.75,;9.94,-14.5,;8.48,-14.99,)| Show InChI InChI=1S/C15H22N6O2S/c1-20(15-13-5-6-16-14(13)17-9-18-15)12-7-10(8-12)19-24(22,23)21(2)11-3-4-11/h5-6,9-12,19H,3-4,7-8H2,1-2H3,(H,16,17,18)/t10-,12+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human JAK1 using 5'FAM-KKSRGDYMTMQID as substrate in presence of 1 mM ATP by mobility shift assay |
J Med Chem 61: 1130-1152 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01598
BindingDB Entry DOI: 10.7270/Q2D79DTW |
More data for this
Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM50243906
(CHEMBL4063642)Show SMILES CN([C@@H]1C[C@@H](C1)NS(=O)(=O)N(C)C1CC1)c1ncnc2[nH]ccc12 |r,wD:2.1,4.6,(5.8,-11.92,;7.14,-12.68,;8.47,-11.91,;8.86,-10.41,;10.35,-10.81,;9.96,-12.3,;11.68,-10.03,;13.01,-10.8,;13.77,-12.13,;12.24,-12.12,;14.35,-10.03,;15.68,-10.8,;14.35,-8.49,;15.13,-7.16,;13.59,-7.16,;7.14,-14.22,;5.81,-15,;5.81,-16.54,;7.15,-17.31,;8.49,-16.53,;9.96,-17,;10.86,-15.75,;9.94,-14.5,;8.48,-14.99,)| Show InChI InChI=1S/C15H22N6O2S/c1-20(15-13-5-6-16-14(13)17-9-18-15)12-7-10(8-12)19-24(22,23)21(2)11-3-4-11/h5-6,9-12,19H,3-4,7-8H2,1-2H3,(H,16,17,18)/t10-,12+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TYK2 using 5'FAM-KKSRGDYMTMQID as substrate in presence of 1 mM ATP by mobility shift assay |
J Med Chem 61: 1130-1152 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01598
BindingDB Entry DOI: 10.7270/Q2D79DTW |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50243906
(CHEMBL4063642)Show SMILES CN([C@@H]1C[C@@H](C1)NS(=O)(=O)N(C)C1CC1)c1ncnc2[nH]ccc12 |r,wD:2.1,4.6,(5.8,-11.92,;7.14,-12.68,;8.47,-11.91,;8.86,-10.41,;10.35,-10.81,;9.96,-12.3,;11.68,-10.03,;13.01,-10.8,;13.77,-12.13,;12.24,-12.12,;14.35,-10.03,;15.68,-10.8,;14.35,-8.49,;15.13,-7.16,;13.59,-7.16,;7.14,-14.22,;5.81,-15,;5.81,-16.54,;7.15,-17.31,;8.49,-16.53,;9.96,-17,;10.86,-15.75,;9.94,-14.5,;8.48,-14.99,)| Show InChI InChI=1S/C15H22N6O2S/c1-20(15-13-5-6-16-14(13)17-9-18-15)12-7-10(8-12)19-24(22,23)21(2)11-3-4-11/h5-6,9-12,19H,3-4,7-8H2,1-2H3,(H,16,17,18)/t10-,12+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 328 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human JAK2 using FITC-KGGEEEEYFELVKK as substrate in presence of 1 mM ATP by mobility shift assay |
J Med Chem 61: 1130-1152 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01598
BindingDB Entry DOI: 10.7270/Q2D79DTW |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50243906
(CHEMBL4063642)Show SMILES CN([C@@H]1C[C@@H](C1)NS(=O)(=O)N(C)C1CC1)c1ncnc2[nH]ccc12 |r,wD:2.1,4.6,(5.8,-11.92,;7.14,-12.68,;8.47,-11.91,;8.86,-10.41,;10.35,-10.81,;9.96,-12.3,;11.68,-10.03,;13.01,-10.8,;13.77,-12.13,;12.24,-12.12,;14.35,-10.03,;15.68,-10.8,;14.35,-8.49,;15.13,-7.16,;13.59,-7.16,;7.14,-14.22,;5.81,-15,;5.81,-16.54,;7.15,-17.31,;8.49,-16.53,;9.96,-17,;10.86,-15.75,;9.94,-14.5,;8.48,-14.99,)| Show InChI InChI=1S/C15H22N6O2S/c1-20(15-13-5-6-16-14(13)17-9-18-15)12-7-10(8-12)19-24(22,23)21(2)11-3-4-11/h5-6,9-12,19H,3-4,7-8H2,1-2H3,(H,16,17,18)/t10-,12+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.67E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium |
J Med Chem 61: 1130-1152 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01598
BindingDB Entry DOI: 10.7270/Q2D79DTW |
More data for this
Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM50243906
(CHEMBL4063642)Show SMILES CN([C@@H]1C[C@@H](C1)NS(=O)(=O)N(C)C1CC1)c1ncnc2[nH]ccc12 |r,wD:2.1,4.6,(5.8,-11.92,;7.14,-12.68,;8.47,-11.91,;8.86,-10.41,;10.35,-10.81,;9.96,-12.3,;11.68,-10.03,;13.01,-10.8,;13.77,-12.13,;12.24,-12.12,;14.35,-10.03,;15.68,-10.8,;14.35,-8.49,;15.13,-7.16,;13.59,-7.16,;7.14,-14.22,;5.81,-15,;5.81,-16.54,;7.15,-17.31,;8.49,-16.53,;9.96,-17,;10.86,-15.75,;9.94,-14.5,;8.48,-14.99,)| Show InChI InChI=1S/C15H22N6O2S/c1-20(15-13-5-6-16-14(13)17-9-18-15)12-7-10(8-12)19-24(22,23)21(2)11-3-4-11/h5-6,9-12,19H,3-4,7-8H2,1-2H3,(H,16,17,18)/t10-,12+ | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 186 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IFNalpha induced STAT3 phosphorylation preincubated for 45 mins followed by IFN... |
J Med Chem 61: 1130-1152 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01598
BindingDB Entry DOI: 10.7270/Q2D79DTW |
More data for this
Ligand-Target Pair | |
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