BDBM50243980 3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-1,5-dihydro-2H-pyrrole-2-one::CHEMBL509435

SMILES: COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1)c1cn(C)c2ccccc12

InChI Key: InChIKey=DUPIINAVKMGMHG-UHFFFAOYSA-N

Data: 12 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50243980   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase B (Homo sapiens (Human))	BDBM50243980 (3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1)c1cn(C)c2ccccc12 |t:13| Show InChI InChI=1S/C22H22N2O4/c1-24-12-16(14-7-5-6-8-17(14)24)20-15(11-23-22(20)25)13-9-18(26-2)21(28-4)19(10-13)27-3/h5-10,12H,11H2,1-4H3,(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls University Curated by ChEMBL					Assay Description Inhibition of human recombinant Aurora B				J Med Chem 51: 3814-24 (2008) Article DOI: 10.1021/jm8001185 BindingDB Entry DOI: 10.7270/Q2057FQS
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM50243980 (3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1)c1cn(C)c2ccccc12 |t:13| Show InChI InChI=1S/C22H22N2O4/c1-24-12-16(14-7-5-6-8-17(14)24)20-15(11-23-22(20)25)13-9-18(26-2)21(28-4)19(10-13)27-3/h5-10,12H,11H2,1-4H3,(H,23,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls University Curated by ChEMBL					Assay Description Inhibition of human recombinant VEGFR3				J Med Chem 51: 3814-24 (2008) Article DOI: 10.1021/jm8001185 BindingDB Entry DOI: 10.7270/Q2057FQS
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50243980 (3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1)c1cn(C)c2ccccc12 |t:13| Show InChI InChI=1S/C22H22N2O4/c1-24-12-16(14-7-5-6-8-17(14)24)20-15(11-23-22(20)25)13-9-18(26-2)21(28-4)19(10-13)27-3/h5-10,12H,11H2,1-4H3,(H,23,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls University Curated by ChEMBL					Assay Description Inhibition of human recombinant INS-R				J Med Chem 51: 3814-24 (2008) Article DOI: 10.1021/jm8001185 BindingDB Entry DOI: 10.7270/Q2057FQS
					More data for this Ligand-Target Pair
NUAK family SNF1-like kinase 1 (Homo sapiens (Human))	BDBM50243980 (3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1)c1cn(C)c2ccccc12 |t:13| Show InChI InChI=1S/C22H22N2O4/c1-24-12-16(14-7-5-6-8-17(14)24)20-15(11-23-22(20)25)13-9-18(26-2)21(28-4)19(10-13)27-3/h5-10,12H,11H2,1-4H3,(H,23,25)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls University Curated by ChEMBL					Assay Description Inhibition of human recombinant ARK5				J Med Chem 51: 3814-24 (2008) Article DOI: 10.1021/jm8001185 BindingDB Entry DOI: 10.7270/Q2057FQS
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50243980 (3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1)c1cn(C)c2ccccc12 |t:13| Show InChI InChI=1S/C22H22N2O4/c1-24-12-16(14-7-5-6-8-17(14)24)20-15(11-23-22(20)25)13-9-18(26-2)21(28-4)19(10-13)27-3/h5-10,12H,11H2,1-4H3,(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls University Curated by ChEMBL					Assay Description Inhibition of human recombinant Aurora A				J Med Chem 51: 3814-24 (2008) Article DOI: 10.1021/jm8001185 BindingDB Entry DOI: 10.7270/Q2057FQS
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 (Homo sapiens (Human))	BDBM50243980 (3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1)c1cn(C)c2ccccc12 |t:13| Show InChI InChI=1S/C22H22N2O4/c1-24-12-16(14-7-5-6-8-17(14)24)20-15(11-23-22(20)25)13-9-18(26-2)21(28-4)19(10-13)27-3/h5-10,12H,11H2,1-4H3,(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls University Curated by ChEMBL					Assay Description Inhibition of human recombinant SAK				J Med Chem 51: 3814-24 (2008) Article DOI: 10.1021/jm8001185 BindingDB Entry DOI: 10.7270/Q2057FQS
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4 (Homo sapiens (Human))	BDBM50243980 (3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1)c1cn(C)c2ccccc12 |t:13| Show InChI InChI=1S/C22H22N2O4/c1-24-12-16(14-7-5-6-8-17(14)24)20-15(11-23-22(20)25)13-9-18(26-2)21(28-4)19(10-13)27-3/h5-10,12H,11H2,1-4H3,(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls University Curated by ChEMBL					Assay Description Inhibition of human recombinant CDK4/cyclin D1				J Med Chem 51: 3814-24 (2008) Article DOI: 10.1021/jm8001185 BindingDB Entry DOI: 10.7270/Q2057FQS
					More data for this Ligand-Target Pair
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM50243980 (3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1)c1cn(C)c2ccccc12 |t:13| Show InChI InChI=1S/C22H22N2O4/c1-24-12-16(14-7-5-6-8-17(14)24)20-15(11-23-22(20)25)13-9-18(26-2)21(28-4)19(10-13)27-3/h5-10,12H,11H2,1-4H3,(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls University Curated by ChEMBL					Assay Description Inhibition of human recombinant FAK				J Med Chem 51: 3814-24 (2008) Article DOI: 10.1021/jm8001185 BindingDB Entry DOI: 10.7270/Q2057FQS
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50243980 (3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1)c1cn(C)c2ccccc12 |t:13| Show InChI InChI=1S/C22H22N2O4/c1-24-12-16(14-7-5-6-8-17(14)24)20-15(11-23-22(20)25)13-9-18(26-2)21(28-4)19(10-13)27-3/h5-10,12H,11H2,1-4H3,(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls University Curated by ChEMBL					Assay Description Inhibition of human recombinant VEGFR2				J Med Chem 51: 3814-24 (2008) Article DOI: 10.1021/jm8001185 BindingDB Entry DOI: 10.7270/Q2057FQS
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50243980 (3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1)c1cn(C)c2ccccc12 |t:13| Show InChI InChI=1S/C22H22N2O4/c1-24-12-16(14-7-5-6-8-17(14)24)20-15(11-23-22(20)25)13-9-18(26-2)21(28-4)19(10-13)27-3/h5-10,12H,11H2,1-4H3,(H,23,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls University Curated by ChEMBL					Assay Description Inhibition of human recombinant FLT3				J Med Chem 51: 3814-24 (2008) Article DOI: 10.1021/jm8001185 BindingDB Entry DOI: 10.7270/Q2057FQS
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50243980 (3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1)c1cn(C)c2ccccc12 |t:13| Show InChI InChI=1S/C22H22N2O4/c1-24-12-16(14-7-5-6-8-17(14)24)20-15(11-23-22(20)25)13-9-18(26-2)21(28-4)19(10-13)27-3/h5-10,12H,11H2,1-4H3,(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDGFRbeta				J Med Chem 51: 3814-24 (2008) Article DOI: 10.1021/jm8001185 BindingDB Entry DOI: 10.7270/Q2057FQS
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50243980 (3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1)c1cn(C)c2ccccc12 |t:13| Show InChI InChI=1S/C22H22N2O4/c1-24-12-16(14-7-5-6-8-17(14)24)20-15(11-23-22(20)25)13-9-18(26-2)21(28-4)19(10-13)27-3/h5-10,12H,11H2,1-4H3,(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls University Curated by ChEMBL					Assay Description Inhibition of human recombinant CDK2/cyclin A				J Med Chem 51: 3814-24 (2008) Article DOI: 10.1021/jm8001185 BindingDB Entry DOI: 10.7270/Q2057FQS
					More data for this Ligand-Target Pair