BindingDB PrimarySearch

BDBM50244035 Beta CCE::CHEMBL454606::cid_105078::ethyl 9H-pyrido[3,4-b]indole-3-carboxylate

SMILES: CCOC(=O)c1cc2c(cn1)[nH]c1ccccc21

InChI Key: InChIKey=KOVRZNUMIKACTB-UHFFFAOYSA-N

Data: 10 KI 2 IC50 2 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50244035
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Gamma-aminobutyric acid receptor subunit alpha-1 (Homo sapiens (Human))	BDBM50244035 (Beta CCE \| CHEMBL454606 \| cid_105078 \| ethyl 9H-py...) Show SMILES CCOC(=O)c1cc2c(cn1)[nH]c1ccccc21 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Clinic for Psychiatry Curated by PDSP K_i Database									Eur J Pharmacol 304: 155-62 (1996) Article DOI: 10.1016/0014-2999(96)00088-x BindingDB Entry DOI: 10.7270/Q2HD7T6P
					More data for this Ligand-Target Pair
GABA receptor alpha-1/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50244035 (Beta CCE \| CHEMBL454606 \| cid_105078 \| ethyl 9H-py...) Show SMILES CCOC(=O)c1cc2c(cn1)[nH]c1ccccc21 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Displacement of [3H]flunitrazepam from human recombinant GABAA alpha1beta3gamma2 receptor expressed in HEK cells by liquid scintillation counting				Bioorg Med Chem 18: 7548-64 (2010) Article DOI: 10.1016/j.bmc.2010.08.049 BindingDB Entry DOI: 10.7270/Q2G1613B
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair
GABA receptor alpha-2/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50244035 (Beta CCE \| CHEMBL454606 \| cid_105078 \| ethyl 9H-py...) Show SMILES CCOC(=O)c1cc2c(cn1)[nH]c1ccccc21 Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Displacement of [3H]flunitrazepam from human recombinant GABAA alpha2beta3gamma2 receptor expressed in HEK cells by liquid scintillation counting				Bioorg Med Chem 18: 7548-64 (2010) Article DOI: 10.1016/j.bmc.2010.08.049 BindingDB Entry DOI: 10.7270/Q2G1613B
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair
GABA receptor alpha-3/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50244035 (Beta CCE \| CHEMBL454606 \| cid_105078 \| ethyl 9H-py...) Show SMILES CCOC(=O)c1cc2c(cn1)[nH]c1ccccc21 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	5.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Displacement of [3H]flunitrazepam from human recombinant GABAA alpha3beta3gamma2 receptor expressed in HEK cells by liquid scintillation counting				Bioorg Med Chem 18: 7548-64 (2010) Article DOI: 10.1016/j.bmc.2010.08.049 BindingDB Entry DOI: 10.7270/Q2G1613B
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50244035 (Beta CCE \| CHEMBL454606 \| cid_105078 \| ethyl 9H-py...) Show SMILES CCOC(=O)c1cc2c(cn1)[nH]c1ccccc21 Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	26.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Displacement of [3H]flunitrazepam from human recombinant GABAA alpha5beta3gamma2 receptor expressed in HEK cells by liquid scintillation counting				Bioorg Med Chem 18: 7548-64 (2010) Article DOI: 10.1016/j.bmc.2010.08.049 BindingDB Entry DOI: 10.7270/Q2G1613B
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair
GABA A Alpha4Beta2Gamma2 (Homo sapiens (Human))	BDBM50244035 (Beta CCE \| CHEMBL454606 \| cid_105078 \| ethyl 9H-py...) Show SMILES CCOC(=O)c1cc2c(cn1)[nH]c1ccccc21 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	693	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Clinic for Psychiatry Curated by PDSP K_i Database									Eur J Pharmacol 304: 155-62 (1996) Article DOI: 10.1016/0014-2999(96)00088-x BindingDB Entry DOI: 10.7270/Q2HD7T6P
					More data for this Ligand-Target Pair
GABA A receptor alpha-6/beta-2/gamma-2 (RAT)	BDBM50244035 (Beta CCE \| CHEMBL454606 \| cid_105078 \| ethyl 9H-py...) Show SMILES CCOC(=O)c1cc2c(cn1)[nH]c1ccccc21 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.62E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes, Digestive, and Kidney Diseases Curated by PDSP K_i Database									Neuropharmacology 35: 1307-14 (1996) Article DOI: 10.1016/s0028-3908(96)00054-8 BindingDB Entry DOI: 10.7270/Q28S4NF7
					More data for this Ligand-Target Pair
GABA receptor alpha-6/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50244035 (Beta CCE \| CHEMBL454606 \| cid_105078 \| ethyl 9H-py...) Show SMILES CCOC(=O)c1cc2c(cn1)[nH]c1ccccc21 Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Displacement of [3H]flunitrazepam from human recombinant GABAA alpha6beta3gamma2 receptor expressed in HEK cells by liquid scintillation counting				Bioorg Med Chem 18: 7548-64 (2010) Article DOI: 10.1016/j.bmc.2010.08.049 BindingDB Entry DOI: 10.7270/Q2G1613B
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Rattus norvegicus (Rat))	BDBM50244035 (Beta CCE \| CHEMBL454606 \| cid_105078 \| ethyl 9H-py...) Show SMILES CCOC(=O)c1cc2c(cn1)[nH]c1ccccc21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.92E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tokyo Dental College Curated by PDSP K_i Database									Biochem Pharmacol 55: 209-14 (1998) Article DOI: 10.1016/s0006-2952(97)00433-4 BindingDB Entry DOI: 10.7270/Q2NP22ZJ
Tokyo Dental College Curated by PDSP K_i Database					More data for this Ligand-Target Pair
GABA A receptor alpha-6/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50244035 (Beta CCE \| CHEMBL454606 \| cid_105078 \| ethyl 9H-py...) Show SMILES CCOC(=O)c1cc2c(cn1)[nH]c1ccccc21 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4.46E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CoCensys, Inc. Curated by PDSP K_i Database									Eur J Pharmacol 291: 319-25 (1995) Article DOI: 10.1016/0922-4106(95)90072-1 BindingDB Entry DOI: 10.7270/Q2JD4VB2
CoCensys, Inc. Curated by PDSP K_i Database					More data for this Ligand-Target Pair
diphosphomevalonate decarboxylase (Streptococcus pneumoniae D39)	BDBM50244035 (Beta CCE \| CHEMBL454606 \| cid_105078 \| ethyl 9H-py...) Show SMILES CCOC(=O)c1cc2c(cn1)[nH]c1ccccc21 Show InChI	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	4.94E+4	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC Curated by PubChem BioAssay					Assay Description Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...				PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2N014XN
SRMLSC Curated by PubChem BioAssay					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Homo sapiens (Human))	BDBM50244035 (Beta CCE \| CHEMBL454606 \| cid_105078 \| ethyl 9H-py...) Show SMILES CCOC(=O)c1cc2c(cn1)[nH]c1ccccc21 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a
Moltech Corporation Curated by ChEMBL					Assay Description Binding affinity to GABAA alpha-1-beta-2-gamma-2 receptor				J Med Chem 51: 3788-803 (2008) Article DOI: 10.1021/jm701433b BindingDB Entry DOI: 10.7270/Q2FQ9XH6
Moltech Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A)) (Homo sapiens (Human))	BDBM50244035 (Beta CCE \| CHEMBL454606 \| cid_105078 \| ethyl 9H-py...) Show SMILES CCOC(=O)c1cc2c(cn1)[nH]c1ccccc21 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a
Moltech Corporation Curated by ChEMBL					Assay Description Binding affinity to GABAA alpha-5-beta-2-gamma-2 receptor				J Med Chem 51: 3788-803 (2008) Article DOI: 10.1021/jm701433b BindingDB Entry DOI: 10.7270/Q2FQ9XH6
Moltech Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50244035 (Beta CCE \| CHEMBL454606 \| cid_105078 \| ethyl 9H-py...) Show SMILES CCOC(=O)c1cc2c(cn1)[nH]c1ccccc21 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	794	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of PDE5 (unknown origin)				J Med Chem 61: 6421-6467 (2018) Article DOI: 10.1021/acs.jmedchem.8b00180 BindingDB Entry DOI: 10.7270/Q2DJ5J62
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair