BDBM50244133 2-(4-tert-Butylphenyl)-4-(4-(2-(2-(trifluoromethyl)-1Hbenzo[d]imidazol-4-yloxy)ethyl)piperazin-1-yl)-1Hbenzo[d]imidazole::CHEMBL444509

SMILES: CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3nc([nH]c23)C(F)(F)F)CC1

InChI Key: InChIKey=UBUCIIFBJIRGAF-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50244133   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gonadotropin releasing hormone 1 (GnRHR1) (Homo sapiens (Human))	BDBM50244133 (2-(4-tert-Butylphenyl)-4-(4-(2-(2-(trifluoromethyl...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3nc([nH]c23)C(F)(F)F)CC1 Show InChI InChI=1S/C31H33F3N6O/c1-30(2,3)21-12-10-20(11-13-21)28-35-22-6-4-8-24(26(22)37-28)40-16-14-39(15-17-40)18-19-41-25-9-5-7-23-27(25)38-29(36-23)31(32,33)34/h4-13H,14-19H2,1-3H3,(H,35,37)(H,36,38)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol production				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin releasing hormone 1 (GnRHR1) (Homo sapiens (Human))	BDBM50244133 (2-(4-tert-Butylphenyl)-4-(4-(2-(2-(trifluoromethyl...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3nc([nH]c23)C(F)(F)F)CC1 Show InChI InChI=1S/C31H33F3N6O/c1-30(2,3)21-12-10-20(11-13-21)28-35-22-6-4-8-24(26(22)37-28)40-16-14-39(15-17-40)18-19-41-25-9-5-7-23-27(25)38-29(36-23)31(32,33)34/h4-13H,14-19H2,1-3H3,(H,35,37)(H,36,38)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50244133 (2-(4-tert-Butylphenyl)-4-(4-(2-(2-(trifluoromethyl...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3nc([nH]c23)C(F)(F)F)CC1 Show InChI InChI=1S/C31H33F3N6O/c1-30(2,3)21-12-10-20(11-13-21)28-35-22-6-4-8-24(26(22)37-28)40-16-14-39(15-17-40)18-19-41-25-9-5-7-23-27(25)38-29(36-23)31(32,33)34/h4-13H,14-19H2,1-3H3,(H,35,37)(H,36,38)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	710	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from rat recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair