BDBM50244175 4-{4-[2-(4-tert-Butyl-phenyl)-1H-benzoimidazol-4-yl]-piperazin-1-ylmethyl}-1,3-dihydro-benzoimidazol-2-one::CHEMBL460892
SMILES: CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2cccc3[nH]c(=O)[nH]c23)CC1
InChI Key: InChIKey=QGMAGELKPVCCBR-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gonadotropin releasing hormone 1 (GnRHR1) (Homo sapiens (Human)) | BDBM50244175 (4-{4-[2-(4-tert-Butyl-phenyl)-1H-benzoimidazol-4-y...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptor | Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gonadotropin-releasing hormone receptor (Rattus norvegicus) | BDBM50244175 (4-{4-[2-(4-tert-Butyl-phenyl)-1H-benzoimidazol-4-y...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Antagonist activity at recombinant GnRH receptor in CO2 asphyxiated rat primary pituitary cells assessed as reduction in (D-Trp6)LHRH-induced LH rele... | Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gonadotropin releasing hormone 1 (GnRHR1) (Homo sapiens (Human)) | BDBM50244175 (4-{4-[2-(4-tert-Butyl-phenyl)-1H-benzoimidazol-4-y...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol production | Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gonadotropin-releasing hormone receptor (Rattus norvegicus) | BDBM50244175 (4-{4-[2-(4-tert-Butyl-phenyl)-1H-benzoimidazol-4-y...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 680 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Displacement of [125I]-(D-Trp6)LHRH from rat recombinant GnRH receptor | Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7 | |||||||||||
More data for this Ligand-Target Pair |