BDBM50244247 1'-{[1-(3-chloropyridin-2-yl)-3-methyl-1H-pyrazol-4-yl]methyl}-3H-spiro[2-benzofuran-1,4'-piperidine]::CHEMBL512520

SMILES: Cc1nn(cc1CN1CCC2(CC1)OCc1ccccc21)-c1ncccc1Cl

InChI Key: InChIKey=WCFLEQVQRJVHDH-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50244247   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50244247 (1'-{[1-(3-chloropyridin-2-yl)-3-methyl-1H-pyrazol-...) Show SMILES Cc1nn(cc1CN1CCC2(CC1)OCc1ccccc21)-c1ncccc1Cl Show InChI InChI=1S/C22H23ClN4O/c1-16-18(14-27(25-16)21-20(23)7-4-10-24-21)13-26-11-8-22(9-12-26)19-6-3-2-5-17(19)15-28-22/h2-7,10,14H,8-9,11-13,15H2,1H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]diprenorphin from human cloned mu opioid receptor expressed in CHO cells				Bioorg Med Chem Lett 18: 3778-82 (2008) Article DOI: 10.1016/j.bmcl.2008.05.036 BindingDB Entry DOI: 10.7270/Q2XD11G6
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50244247 (1'-{[1-(3-chloropyridin-2-yl)-3-methyl-1H-pyrazol-...) Show SMILES Cc1nn(cc1CN1CCC2(CC1)OCc1ccccc21)-c1ncccc1Cl Show InChI InChI=1S/C22H23ClN4O/c1-16-18(14-27(25-16)21-20(23)7-4-10-24-21)13-26-11-8-22(9-12-26)19-6-3-2-5-17(19)15-28-22/h2-7,10,14H,8-9,11-13,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [35S]MK499 from human ERG in HEK293 cell membrane				Bioorg Med Chem Lett 18: 3778-82 (2008) Article DOI: 10.1016/j.bmcl.2008.05.036 BindingDB Entry DOI: 10.7270/Q2XD11G6
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50244247 (1'-{[1-(3-chloropyridin-2-yl)-3-methyl-1H-pyrazol-...) Show SMILES Cc1nn(cc1CN1CCC2(CC1)OCc1ccccc21)-c1ncccc1Cl Show InChI InChI=1S/C22H23ClN4O/c1-16-18(14-27(25-16)21-20(23)7-4-10-24-21)13-26-11-8-22(9-12-26)19-6-3-2-5-17(19)15-28-22/h2-7,10,14H,8-9,11-13,15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]U69593 from human cloned kappa opioid receptor expressed in CHO cells				Bioorg Med Chem Lett 18: 3778-82 (2008) Article DOI: 10.1016/j.bmcl.2008.05.036 BindingDB Entry DOI: 10.7270/Q2XD11G6
					More data for this Ligand-Target Pair