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BDBM50244890 CHEMBL472535::N-(2-fluorophenyl)-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

SMILES: Fc1ccccc1NC(=O)N1CCN(CC1)c1nc(ns1)-c1ccccc1

InChI Key: InChIKey=VMEFMXDKUPNZBH-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50244890   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fatty-acid amide hydrolase 1 (aa 30-579)


(Rattus norvegicus (rat))
BDBM50244890
PNG
(CHEMBL472535 | N-(2-fluorophenyl)-4-(3-phenyl-1,2,...)
Show SMILES Fc1ccccc1NC(=O)N1CCN(CC1)c1nc(ns1)-c1ccccc1
Show InChI InChI=1S/C19H18FN5OS/c20-15-8-4-5-9-16(15)21-18(26)24-10-12-25(13-11-24)19-22-17(23-27-19)14-6-2-1-3-7-14/h1-9H,10-13H2,(H,21,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 6.20n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat FAAH preincubated for 20 mins


Bioorg Med Chem Lett 18: 4838-43 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.081
BindingDB Entry DOI: 10.7270/Q23T9H2B
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 (aa 30-579)


(Rattus norvegicus (rat))
BDBM50244890
PNG
(CHEMBL472535 | N-(2-fluorophenyl)-4-(3-phenyl-1,2,...)
Show SMILES Fc1ccccc1NC(=O)N1CCN(CC1)c1nc(ns1)-c1ccccc1
Show InChI InChI=1S/C19H18FN5OS/c20-15-8-4-5-9-16(15)21-18(26)24-10-12-25(13-11-24)19-22-17(23-27-19)14-6-2-1-3-7-14/h1-9H,10-13H2,(H,21,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat FAAH assessed as hydrolysis of anandamidoaminomethylcumarin


Bioorg Med Chem Lett 21: 2492-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.052
BindingDB Entry DOI: 10.7270/Q2BG2P9M
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50244890
PNG
(CHEMBL472535 | N-(2-fluorophenyl)-4-(3-phenyl-1,2,...)
Show SMILES Fc1ccccc1NC(=O)N1CCN(CC1)c1nc(ns1)-c1ccccc1
Show InChI InChI=1S/C19H18FN5OS/c20-15-8-4-5-9-16(15)21-18(26)24-10-12-25(13-11-24)19-22-17(23-27-19)14-6-2-1-3-7-14/h1-9H,10-13H2,(H,21,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human FAAH assessed as hydrolysis of anandamidoaminomethylcumarin


Bioorg Med Chem Lett 21: 2492-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.052
BindingDB Entry DOI: 10.7270/Q2BG2P9M
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50244890
PNG
(CHEMBL472535 | N-(2-fluorophenyl)-4-(3-phenyl-1,2,...)
Show SMILES Fc1ccccc1NC(=O)N1CCN(CC1)c1nc(ns1)-c1ccccc1
Show InChI InChI=1S/C19H18FN5OS/c20-15-8-4-5-9-16(15)21-18(26)24-10-12-25(13-11-24)19-22-17(23-27-19)14-6-2-1-3-7-14/h1-9H,10-13H2,(H,21,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 19n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human FAAH preincubated for 20 mins


Bioorg Med Chem Lett 18: 4838-43 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.081
BindingDB Entry DOI: 10.7270/Q23T9H2B
More data for this
Ligand-Target Pair