BDBM50245145 4-(2,6-dichlorophenyl)-9-hydroxy-6-(3-morpholinopropyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione::CHEMBL486828

SMILES: Oc1ccc2n(CCCN3CCOCC3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1c(Cl)cccc1Cl

InChI Key: InChIKey=VCILCSWAAWCHHY-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50245145   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50245145 (4-(2,6-dichlorophenyl)-9-hydroxy-6-(3-morpholinopr...) Show SMILES Oc1ccc2n(CCCN3CCOCC3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1c(Cl)cccc1Cl |(17.89,-39.21,;19.22,-39.98,;19.22,-41.52,;20.56,-42.29,;21.9,-41.52,;23.38,-41.99,;23.86,-43.45,;22.84,-44.61,;23.33,-46.07,;22.3,-47.22,;20.79,-46.91,;19.77,-48.05,;20.25,-49.52,;21.76,-49.83,;22.79,-48.68,;24.28,-40.73,;25.81,-40.56,;26.43,-39.14,;25.5,-37.9,;25.81,-36.4,;27.22,-35.76,;24.48,-35.64,;23.34,-36.67,;21.83,-36.36,;23.98,-38.07,;23.36,-39.48,;21.89,-39.97,;20.55,-39.21,;27.96,-38.97,;28.87,-40.21,;28.26,-41.62,;30.4,-40.04,;31.02,-38.62,;30.09,-37.38,;28.57,-37.56,;28.55,-36.02,)| Show InChI InChI=1S/C27H23Cl2N3O4/c28-18-3-1-4-19(29)22(18)17-14-21-23(25-24(17)26(34)30-27(25)35)16-13-15(33)5-6-20(16)32(21)8-2-7-31-9-11-36-12-10-31/h1,3-6,13-14,33H,2,7-12H2,(H,30,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylation				Eur J Med Chem 43: 1276-96 (2008) Article DOI: 10.1016/j.ejmech.2007.07.016 BindingDB Entry DOI: 10.7270/Q26M36MC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50245145 (4-(2,6-dichlorophenyl)-9-hydroxy-6-(3-morpholinopr...) Show SMILES Oc1ccc2n(CCCN3CCOCC3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1c(Cl)cccc1Cl |(17.89,-39.21,;19.22,-39.98,;19.22,-41.52,;20.56,-42.29,;21.9,-41.52,;23.38,-41.99,;23.86,-43.45,;22.84,-44.61,;23.33,-46.07,;22.3,-47.22,;20.79,-46.91,;19.77,-48.05,;20.25,-49.52,;21.76,-49.83,;22.79,-48.68,;24.28,-40.73,;25.81,-40.56,;26.43,-39.14,;25.5,-37.9,;25.81,-36.4,;27.22,-35.76,;24.48,-35.64,;23.34,-36.67,;21.83,-36.36,;23.98,-38.07,;23.36,-39.48,;21.89,-39.97,;20.55,-39.21,;27.96,-38.97,;28.87,-40.21,;28.26,-41.62,;30.4,-40.04,;31.02,-38.62,;30.09,-37.38,;28.57,-37.56,;28.55,-36.02,)| Show InChI InChI=1S/C27H23Cl2N3O4/c28-18-3-1-4-19(29)22(18)17-14-21-23(25-24(17)26(34)30-27(25)35)16-13-15(33)5-6-20(16)32(21)8-2-7-31-9-11-36-12-10-31/h1,3-6,13-14,33H,2,7-12H2,(H,30,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determination				Eur J Med Chem 43: 1276-96 (2008) Article DOI: 10.1016/j.ejmech.2007.07.016 BindingDB Entry DOI: 10.7270/Q26M36MC
					More data for this Ligand-Target Pair