BDBM50245147 6-(3-(1H-imidazol-1-yl)propyl)-4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione::CHEMBL486665

SMILES: Oc1ccc2n(CCCn3ccnc3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1Cl

InChI Key: InChIKey=PHEFAXAJDWAROH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50245147   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50245147 (6-(3-(1H-imidazol-1-yl)propyl)-4-(2-chlorophenyl)-...) Show SMILES Oc1ccc2n(CCCn3ccnc3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1Cl Show InChI InChI=1S/C26H19ClN4O3/c27-19-5-2-1-4-16(19)17-13-21-22(24-23(17)25(33)29-26(24)34)18-12-15(32)6-7-20(18)31(21)10-3-9-30-11-8-28-14-30/h1-2,4-8,11-14,32H,3,9-10H2,(H,29,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylation				Eur J Med Chem 43: 1276-96 (2008) Article DOI: 10.1016/j.ejmech.2007.07.016 BindingDB Entry DOI: 10.7270/Q26M36MC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50245147 (6-(3-(1H-imidazol-1-yl)propyl)-4-(2-chlorophenyl)-...) Show SMILES Oc1ccc2n(CCCn3ccnc3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1Cl Show InChI InChI=1S/C26H19ClN4O3/c27-19-5-2-1-4-16(19)17-13-21-22(24-23(17)25(33)29-26(24)34)18-12-15(32)6-7-20(18)31(21)10-3-9-30-11-8-28-14-30/h1-2,4-8,11-14,32H,3,9-10H2,(H,29,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determination				Eur J Med Chem 43: 1276-96 (2008) Article DOI: 10.1016/j.ejmech.2007.07.016 BindingDB Entry DOI: 10.7270/Q26M36MC
					More data for this Ligand-Target Pair