BDBM50245363 4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-phenylpyrimidine-5-carboxamide::CHEMBL461114

SMILES: Nc1ncnc(Nc2ccc(OCc3ccccc3)c(Cl)c2)c1C(=O)Nc1ccccc1

InChI Key: InChIKey=CYQGGEIFCSVNDW-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50245363   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50245363 (4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-ph...) Show SMILES Nc1ncnc(Nc2ccc(OCc3ccccc3)c(Cl)c2)c1C(=O)Nc1ccccc1 Show InChI InChI=1S/C24H20ClN5O2/c25-19-13-18(11-12-20(19)32-14-16-7-3-1-4-8-16)29-23-21(22(26)27-15-28-23)24(31)30-17-9-5-2-6-10-17/h1-13,15H,14H2,(H,30,31)(H3,26,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibition of EGFR (unknown origin)				Bioorg Med Chem Lett 18: 4896-9 (2008) Article DOI: 10.1016/j.bmcl.2008.07.057 BindingDB Entry DOI: 10.7270/Q2NS0TPB
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50245363 (4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-ph...) Show SMILES Nc1ncnc(Nc2ccc(OCc3ccccc3)c(Cl)c2)c1C(=O)Nc1ccccc1 Show InChI InChI=1S/C24H20ClN5O2/c25-19-13-18(11-12-20(19)32-14-16-7-3-1-4-8-16)29-23-21(22(26)27-15-28-23)24(31)30-17-9-5-2-6-10-17/h1-13,15H,14H2,(H,30,31)(H3,26,27,28,29)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	776	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibition of HER2 (unknown origin)				Bioorg Med Chem Lett 18: 4896-9 (2008) Article DOI: 10.1016/j.bmcl.2008.07.057 BindingDB Entry DOI: 10.7270/Q2NS0TPB
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50245363 (4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-ph...) Show SMILES Nc1ncnc(Nc2ccc(OCc3ccccc3)c(Cl)c2)c1C(=O)Nc1ccccc1 Show InChI InChI=1S/C24H20ClN5O2/c25-19-13-18(11-12-20(19)32-14-16-7-3-1-4-8-16)29-23-21(22(26)27-15-28-23)24(31)30-17-9-5-2-6-10-17/h1-13,15H,14H2,(H,30,31)(H3,26,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin)				Bioorg Med Chem Lett 18: 4896-9 (2008) Article DOI: 10.1016/j.bmcl.2008.07.057 BindingDB Entry DOI: 10.7270/Q2NS0TPB
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Homo sapiens (Human))	BDBM50245363 (4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-ph...) Show SMILES Nc1ncnc(Nc2ccc(OCc3ccccc3)c(Cl)c2)c1C(=O)Nc1ccccc1 Show InChI InChI=1S/C24H20ClN5O2/c25-19-13-18(11-12-20(19)32-14-16-7-3-1-4-8-16)29-23-21(22(26)27-15-28-23)24(31)30-17-9-5-2-6-10-17/h1-13,15H,14H2,(H,30,31)(H3,26,27,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibition of CDK1 (unknown origin)				Bioorg Med Chem Lett 18: 4896-9 (2008) Article DOI: 10.1016/j.bmcl.2008.07.057 BindingDB Entry DOI: 10.7270/Q2NS0TPB
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50245363 (4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-ph...) Show SMILES Nc1ncnc(Nc2ccc(OCc3ccccc3)c(Cl)c2)c1C(=O)Nc1ccccc1 Show InChI InChI=1S/C24H20ClN5O2/c25-19-13-18(11-12-20(19)32-14-16-7-3-1-4-8-16)29-23-21(22(26)27-15-28-23)24(31)30-17-9-5-2-6-10-17/h1-13,15H,14H2,(H,30,31)(H3,26,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibition of Aurora A (unknown origin)				Bioorg Med Chem Lett 18: 4896-9 (2008) Article DOI: 10.1016/j.bmcl.2008.07.057 BindingDB Entry DOI: 10.7270/Q2NS0TPB
					More data for this Ligand-Target Pair