BDBM50245376 CHEMBL462349::N-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-1H-indazol-3-yl)-4-(trifluoromethyl)benzamide

SMILES: COc1cc2nccc(Oc3ccc4c(NC(=O)c5ccc(cc5)C(F)(F)F)nn(C)c4c3)c2cc1OC

InChI Key: InChIKey=FLBOVCXPJRCWAS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50245376   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50245376 (CHEMBL462349 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...) Show SMILES COc1cc2nccc(Oc3ccc4c(NC(=O)c5ccc(cc5)C(F)(F)F)nn(C)c4c3)c2cc1OC Show InChI InChI=1S/C27H21F3N4O4/c1-34-21-12-17(38-22-10-11-31-20-14-24(37-3)23(36-2)13-19(20)22)8-9-18(21)25(33-34)32-26(35)15-4-6-16(7-5-15)27(28,29)30/h4-14H,1-3H3,(H,32,33,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant KDR by HTRF assay				Bioorg Med Chem Lett 18: 4844-8 (2008) Article DOI: 10.1016/j.bmcl.2008.07.080 BindingDB Entry DOI: 10.7270/Q2W9591V
					More data for this Ligand-Target Pair