Found 4 hits for monomerid = 50245442 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM50245442
(3-fluorobenzyl 4-amino-6-(4-(benzyloxy)-3-chloroph...)Show SMILES Nc1ncnc(Nc2ccc(OCc3ccccc3)c(Cl)c2)c1C(=O)OCc1cccc(F)c1 Show InChI InChI=1S/C25H20ClFN4O3/c26-20-12-19(9-10-21(20)33-13-16-5-2-1-3-6-16)31-24-22(23(28)29-15-30-24)25(32)34-14-17-7-4-8-18(27)11-17/h1-12,15H,13-14H2,(H3,28,29,30,31) | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of HER2 (unknown origin) |
Bioorg Med Chem Lett 18: 4896-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.057 BindingDB Entry DOI: 10.7270/Q2NS0TPB |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50245442
(3-fluorobenzyl 4-amino-6-(4-(benzyloxy)-3-chloroph...)Show SMILES Nc1ncnc(Nc2ccc(OCc3ccccc3)c(Cl)c2)c1C(=O)OCc1cccc(F)c1 Show InChI InChI=1S/C25H20ClFN4O3/c26-20-12-19(9-10-21(20)33-13-16-5-2-1-3-6-16)31-24-22(23(28)29-15-30-24)25(32)34-14-17-7-4-8-18(27)11-17/h1-12,15H,13-14H2,(H3,28,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of VEGFR2 (unknown origin) |
Bioorg Med Chem Lett 18: 4896-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.057 BindingDB Entry DOI: 10.7270/Q2NS0TPB |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50245442
(3-fluorobenzyl 4-amino-6-(4-(benzyloxy)-3-chloroph...)Show SMILES Nc1ncnc(Nc2ccc(OCc3ccccc3)c(Cl)c2)c1C(=O)OCc1cccc(F)c1 Show InChI InChI=1S/C25H20ClFN4O3/c26-20-12-19(9-10-21(20)33-13-16-5-2-1-3-6-16)31-24-22(23(28)29-15-30-24)25(32)34-14-17-7-4-8-18(27)11-17/h1-12,15H,13-14H2,(H3,28,29,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of CDK1 (unknown origin) |
Bioorg Med Chem Lett 18: 4896-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.057 BindingDB Entry DOI: 10.7270/Q2NS0TPB |
More data for this Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50245442
(3-fluorobenzyl 4-amino-6-(4-(benzyloxy)-3-chloroph...)Show SMILES Nc1ncnc(Nc2ccc(OCc3ccccc3)c(Cl)c2)c1C(=O)OCc1cccc(F)c1 Show InChI InChI=1S/C25H20ClFN4O3/c26-20-12-19(9-10-21(20)33-13-16-5-2-1-3-6-16)31-24-22(23(28)29-15-30-24)25(32)34-14-17-7-4-8-18(27)11-17/h1-12,15H,13-14H2,(H3,28,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of Aurora A (unknown origin) |
Bioorg Med Chem Lett 18: 4896-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.057 BindingDB Entry DOI: 10.7270/Q2NS0TPB |
More data for this Ligand-Target Pair | |