BDBM50245575 4-(2,6-dichlorophenyl)-6-(2-(dimethylamino)ethyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione::CHEMBL487031

SMILES: CN(C)CCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1c(Cl)cccc1Cl

InChI Key: InChIKey=KELNBNJQBQGRDM-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50245575   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50245575 (4-(2,6-dichlorophenyl)-6-(2-(dimethylamino)ethyl)-...) Show SMILES CN(C)CCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1c(Cl)cccc1Cl |(24.43,-31.38,;22.93,-31.06,;21.9,-32.21,;22.45,-29.6,;23.48,-28.45,;23,-26.99,;21.52,-26.51,;20.19,-27.28,;18.86,-26.51,;18.86,-24.97,;17.52,-24.2,;20.19,-24.2,;21.52,-24.96,;23,-24.48,;23.63,-23.07,;23,-21.67,;21.5,-21.34,;24.15,-20.64,;25.48,-21.41,;26.88,-20.79,;25.15,-22.91,;26.08,-24.17,;25.44,-25.58,;23.9,-25.74,;27.6,-24.01,;28.5,-25.26,;27.88,-26.66,;30.03,-25.1,;30.66,-23.69,;29.75,-22.44,;28.22,-22.61,;28.21,-21.06,)| Show InChI InChI=1S/C24H19Cl2N3O3/c1-28(2)8-9-29-17-7-6-12(30)10-13(17)20-18(29)11-14(19-15(25)4-3-5-16(19)26)21-22(20)24(32)27-23(21)31/h3-7,10-11,30H,8-9H2,1-2H3,(H,27,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	850	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determination				Eur J Med Chem 43: 1276-96 (2008) Article DOI: 10.1016/j.ejmech.2007.07.016 BindingDB Entry DOI: 10.7270/Q26M36MC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50245575 (4-(2,6-dichlorophenyl)-6-(2-(dimethylamino)ethyl)-...) Show SMILES CN(C)CCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1c(Cl)cccc1Cl |(24.43,-31.38,;22.93,-31.06,;21.9,-32.21,;22.45,-29.6,;23.48,-28.45,;23,-26.99,;21.52,-26.51,;20.19,-27.28,;18.86,-26.51,;18.86,-24.97,;17.52,-24.2,;20.19,-24.2,;21.52,-24.96,;23,-24.48,;23.63,-23.07,;23,-21.67,;21.5,-21.34,;24.15,-20.64,;25.48,-21.41,;26.88,-20.79,;25.15,-22.91,;26.08,-24.17,;25.44,-25.58,;23.9,-25.74,;27.6,-24.01,;28.5,-25.26,;27.88,-26.66,;30.03,-25.1,;30.66,-23.69,;29.75,-22.44,;28.22,-22.61,;28.21,-21.06,)| Show InChI InChI=1S/C24H19Cl2N3O3/c1-28(2)8-9-29-17-7-6-12(30)10-13(17)20-18(29)11-14(19-15(25)4-3-5-16(19)26)21-22(20)24(32)27-23(21)31/h3-7,10-11,30H,8-9H2,1-2H3,(H,27,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Chulalongkorn University Curated by ChEMBL					Assay Description Inhibition of human Wee1				Eur J Med Chem 44: 1383-95 (2009) Article DOI: 10.1016/j.ejmech.2008.09.027 BindingDB Entry DOI: 10.7270/Q2X34XB6
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50245575 (4-(2,6-dichlorophenyl)-6-(2-(dimethylamino)ethyl)-...) Show SMILES CN(C)CCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1c(Cl)cccc1Cl |(24.43,-31.38,;22.93,-31.06,;21.9,-32.21,;22.45,-29.6,;23.48,-28.45,;23,-26.99,;21.52,-26.51,;20.19,-27.28,;18.86,-26.51,;18.86,-24.97,;17.52,-24.2,;20.19,-24.2,;21.52,-24.96,;23,-24.48,;23.63,-23.07,;23,-21.67,;21.5,-21.34,;24.15,-20.64,;25.48,-21.41,;26.88,-20.79,;25.15,-22.91,;26.08,-24.17,;25.44,-25.58,;23.9,-25.74,;27.6,-24.01,;28.5,-25.26,;27.88,-26.66,;30.03,-25.1,;30.66,-23.69,;29.75,-22.44,;28.22,-22.61,;28.21,-21.06,)| Show InChI InChI=1S/C24H19Cl2N3O3/c1-28(2)8-9-29-17-7-6-12(30)10-13(17)20-18(29)11-14(19-15(25)4-3-5-16(19)26)21-22(20)24(32)27-23(21)31/h3-7,10-11,30H,8-9H2,1-2H3,(H,27,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylation				Eur J Med Chem 43: 1276-96 (2008) Article DOI: 10.1016/j.ejmech.2007.07.016 BindingDB Entry DOI: 10.7270/Q26M36MC
					More data for this Ligand-Target Pair