BDBM50245622 6-(2-(1H-imidazol-1-yl)ethyl)-9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione::CHEMBL488899

SMILES: Oc1ccc2n(CCn3ccnc3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1

InChI Key: InChIKey=ARBSTLGRZNKZRL-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50245622   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50245622 (6-(2-(1H-imidazol-1-yl)ethyl)-9-hydroxy-4-phenylpy...) Show SMILES Oc1ccc2n(CCn3ccnc3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1 Show InChI InChI=1S/C25H18N4O3/c30-16-6-7-19-18(12-16)21-20(29(19)11-10-28-9-8-26-14-28)13-17(15-4-2-1-3-5-15)22-23(21)25(32)27-24(22)31/h1-9,12-14,30H,10-11H2,(H,27,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determination				Eur J Med Chem 43: 1276-96 (2008) Article DOI: 10.1016/j.ejmech.2007.07.016 BindingDB Entry DOI: 10.7270/Q26M36MC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50245622 (6-(2-(1H-imidazol-1-yl)ethyl)-9-hydroxy-4-phenylpy...) Show SMILES Oc1ccc2n(CCn3ccnc3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1 Show InChI InChI=1S/C25H18N4O3/c30-16-6-7-19-18(12-16)21-20(29(19)11-10-28-9-8-26-14-28)13-17(15-4-2-1-3-5-15)22-23(21)25(32)27-24(22)31/h1-9,12-14,30H,10-11H2,(H,27,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylation				Eur J Med Chem 43: 1276-96 (2008) Article DOI: 10.1016/j.ejmech.2007.07.016 BindingDB Entry DOI: 10.7270/Q26M36MC
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50245622 (6-(2-(1H-imidazol-1-yl)ethyl)-9-hydroxy-4-phenylpy...) Show SMILES Oc1ccc2n(CCn3ccnc3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1 Show InChI InChI=1S/C25H18N4O3/c30-16-6-7-19-18(12-16)21-20(29(19)11-10-28-9-8-26-14-28)13-17(15-4-2-1-3-5-15)22-23(21)25(32)27-24(22)31/h1-9,12-14,30H,10-11H2,(H,27,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of c-Src				Eur J Med Chem 43: 1276-96 (2008) Article DOI: 10.1016/j.ejmech.2007.07.016 BindingDB Entry DOI: 10.7270/Q26M36MC
					More data for this Ligand-Target Pair