BDBM50245690 6-(2-(1H-imidazol-1-yl)ethyl)-4-(2,6-dichlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione::CHEMBL508294

SMILES: Oc1ccc2n(CCn3ccnc3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1c(Cl)cccc1Cl

InChI Key: InChIKey=PNTYTKGROPLTAM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50245690   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50245690 (6-(2-(1H-imidazol-1-yl)ethyl)-4-(2,6-dichloropheny...) Show SMILES Oc1ccc2n(CCn3ccnc3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1c(Cl)cccc1Cl |(18.24,2.81,;19.57,2.04,;19.57,.49,;20.91,-.28,;22.25,.49,;23.73,.02,;24.21,-1.44,;23.19,-2.59,;23.68,-4.05,;25.14,-4.52,;25.16,-6.06,;23.69,-6.54,;22.78,-5.3,;24.63,1.28,;26.16,1.45,;26.78,2.87,;25.85,4.11,;26.16,5.62,;27.57,6.25,;24.83,6.38,;23.69,5.34,;22.18,5.65,;24.33,3.94,;23.71,2.53,;22.24,2.04,;20.9,2.81,;28.31,3.05,;29.22,1.81,;28.61,.39,;30.75,1.98,;31.37,3.39,;30.44,4.64,;28.92,4.45,;28.9,6,)| Show InChI InChI=1S/C25H16Cl2N4O3/c26-16-2-1-3-17(27)20(16)15-11-19-21(23-22(15)24(33)29-25(23)34)14-10-13(32)4-5-18(14)31(19)9-8-30-7-6-28-12-30/h1-7,10-12,32H,8-9H2,(H,29,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylation				Eur J Med Chem 43: 1276-96 (2008) Article DOI: 10.1016/j.ejmech.2007.07.016 BindingDB Entry DOI: 10.7270/Q26M36MC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50245690 (6-(2-(1H-imidazol-1-yl)ethyl)-4-(2,6-dichloropheny...) Show SMILES Oc1ccc2n(CCn3ccnc3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1c(Cl)cccc1Cl |(18.24,2.81,;19.57,2.04,;19.57,.49,;20.91,-.28,;22.25,.49,;23.73,.02,;24.21,-1.44,;23.19,-2.59,;23.68,-4.05,;25.14,-4.52,;25.16,-6.06,;23.69,-6.54,;22.78,-5.3,;24.63,1.28,;26.16,1.45,;26.78,2.87,;25.85,4.11,;26.16,5.62,;27.57,6.25,;24.83,6.38,;23.69,5.34,;22.18,5.65,;24.33,3.94,;23.71,2.53,;22.24,2.04,;20.9,2.81,;28.31,3.05,;29.22,1.81,;28.61,.39,;30.75,1.98,;31.37,3.39,;30.44,4.64,;28.92,4.45,;28.9,6,)| Show InChI InChI=1S/C25H16Cl2N4O3/c26-16-2-1-3-17(27)20(16)15-11-19-21(23-22(15)24(33)29-25(23)34)14-10-13(32)4-5-18(14)31(19)9-8-30-7-6-28-12-30/h1-7,10-12,32H,8-9H2,(H,29,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determination				Eur J Med Chem 43: 1276-96 (2008) Article DOI: 10.1016/j.ejmech.2007.07.016 BindingDB Entry DOI: 10.7270/Q26M36MC
					More data for this Ligand-Target Pair