BDBM50245769 1-(2-chloro-4-(trifluoromethyl)phenyl)-3-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-1H-indazol-3-yl)urea::CHEMBL452088

SMILES: COc1cc2nccc(Oc3ccc4c(NC(=O)Nc5ccc(cc5Cl)C(F)(F)F)nn(C)c4c3)c2cc1OC

InChI Key: InChIKey=XZVLDNHMTPTVMS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50245769   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50245769 (1-(2-chloro-4-(trifluoromethyl)phenyl)-3-(6-(6,7-d...) Show SMILES COc1cc2nccc(Oc3ccc4c(NC(=O)Nc5ccc(cc5Cl)C(F)(F)F)nn(C)c4c3)c2cc1OC Show InChI InChI=1S/C27H21ClF3N5O4/c1-36-21-11-15(40-22-8-9-32-20-13-24(39-3)23(38-2)12-17(20)22)5-6-16(21)25(35-36)34-26(37)33-19-7-4-14(10-18(19)28)27(29,30)31/h4-13H,1-3H3,(H2,33,34,35,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant KDR by HTRF assay				Bioorg Med Chem Lett 18: 4844-8 (2008) Article DOI: 10.1016/j.bmcl.2008.07.080 BindingDB Entry DOI: 10.7270/Q2W9591V
					More data for this Ligand-Target Pair