BDBM50245798 (R)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2-(1-(pyridin-2-yl)ethoxy)pyridin-3-yl)-2-methyl-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one::CHEMBL455187
SMILES: CCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)c2ccccn2)c(c1)-c1nc2c(CC)n(C)nc2c(=O)[nH]1
InChI Key: InChIKey=FCMDGPPBCUEITO-QGZVFWFLSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Canis familiaris) | BDBM50245798 ((R)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of canine retina PDE6 by scintillation proximity assay | Bioorg Med Chem Lett 18: 6033-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.037 BindingDB Entry DOI: 10.7270/Q2H131WT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM50245798 ((R)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of human corpus cavernosum PDE5 by scintillation proximity assay | Bioorg Med Chem Lett 18: 6033-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.037 BindingDB Entry DOI: 10.7270/Q2H131WT | |||||||||||
More data for this Ligand-Target Pair |