BDBM50246098 5-(5-methyl-4-(pyridin-2-ylmethylamino)pyrimidin-2-ylamino)indolin-2-one::CHEMBL471698

SMILES: Cc1cnc(Nc2ccc3NC(=O)Cc3c2)nc1NCc1ccccn1

InChI Key: InChIKey=MRGDFKGWULXLAK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50246098   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PTK2B protein tyrosine kinase 2 beta (PTK2B) (Homo sapiens (Human))	BDBM50246098 (5-(5-methyl-4-(pyridin-2-ylmethylamino)pyrimidin-2...) Show SMILES Cc1cnc(Nc2ccc3NC(=O)Cc3c2)nc1NCc1ccccn1 Show InChI InChI=1S/C19H18N6O/c1-12-10-22-19(25-18(12)21-11-15-4-2-3-7-20-15)23-14-5-6-16-13(8-14)9-17(26)24-16/h2-8,10H,9,11H2,1H3,(H,24,26)(H2,21,22,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of GST-tagged pyk2 (unknown origin) assessed as inhibition of poly-Glu-Tyr phosphorylation				Bioorg Med Chem Lett 18: 6071-7 (2008) Article DOI: 10.1016/j.bmcl.2008.10.030 BindingDB Entry DOI: 10.7270/Q2C8295H
					More data for this Ligand-Target Pair
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM50246098 (5-(5-methyl-4-(pyridin-2-ylmethylamino)pyrimidin-2...) Show SMILES Cc1cnc(Nc2ccc3NC(=O)Cc3c2)nc1NCc1ccccn1 Show InChI InChI=1S/C19H18N6O/c1-12-10-22-19(25-18(12)21-11-15-4-2-3-7-20-15)23-14-5-6-16-13(8-14)9-17(26)24-16/h2-8,10H,9,11H2,1H3,(H,24,26)(H2,21,22,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of GST-tagged FAK (unknown origin) assessed as inhibition of poly-Glu-Tyr phosphorylation				Bioorg Med Chem Lett 18: 6071-7 (2008) Article DOI: 10.1016/j.bmcl.2008.10.030 BindingDB Entry DOI: 10.7270/Q2C8295H
					More data for this Ligand-Target Pair