BDBM50246138 2-(2-oxoindolin-5-ylamino)-4-(pyridin-2-ylmethylamino)pyrimidine-5-carbonitrile::CHEMBL470317

SMILES: O=C1Cc2cc(Nc3ncc(C#N)c(NCc4ccccn4)n3)ccc2N1

InChI Key: InChIKey=NZMLNSPBNGKNHW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50246138   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PTK2B protein tyrosine kinase 2 beta (PTK2B) (Homo sapiens (Human))	BDBM50246138 (2-(2-oxoindolin-5-ylamino)-4-(pyridin-2-ylmethylam...) Show SMILES O=C1Cc2cc(Nc3ncc(C#N)c(NCc4ccccn4)n3)ccc2N1 Show InChI InChI=1S/C19H15N7O/c20-9-13-10-23-19(26-18(13)22-11-15-3-1-2-6-21-15)24-14-4-5-16-12(7-14)8-17(27)25-16/h1-7,10H,8,11H2,(H,25,27)(H2,22,23,24,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of GST-tagged pyk2 (unknown origin) assessed as inhibition of poly-Glu-Tyr phosphorylation				Bioorg Med Chem Lett 18: 6071-7 (2008) Article DOI: 10.1016/j.bmcl.2008.10.030 BindingDB Entry DOI: 10.7270/Q2C8295H
					More data for this Ligand-Target Pair
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM50246138 (2-(2-oxoindolin-5-ylamino)-4-(pyridin-2-ylmethylam...) Show SMILES O=C1Cc2cc(Nc3ncc(C#N)c(NCc4ccccn4)n3)ccc2N1 Show InChI InChI=1S/C19H15N7O/c20-9-13-10-23-19(26-18(13)22-11-15-3-1-2-6-21-15)24-14-4-5-16-12(7-14)8-17(27)25-16/h1-7,10H,8,11H2,(H,25,27)(H2,22,23,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of GST-tagged FAK (unknown origin) assessed as inhibition of poly-Glu-Tyr phosphorylation				Bioorg Med Chem Lett 18: 6071-7 (2008) Article DOI: 10.1016/j.bmcl.2008.10.030 BindingDB Entry DOI: 10.7270/Q2C8295H
					More data for this Ligand-Target Pair