BDBM50246238 7-(4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one::CHEMBL487228

SMILES: FC(F)(F)c1cnc(Nc2ccc3NC(=O)CCCc3c2)nc1NC1CCC1

InChI Key: InChIKey=YGXQGDCKKNZRJA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50246238   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PTK2B protein tyrosine kinase 2 beta (PTK2B) (Homo sapiens (Human))	BDBM50246238 (7-(4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidi...) Show SMILES FC(F)(F)c1cnc(Nc2ccc3NC(=O)CCCc3c2)nc1NC1CCC1 Show InChI InChI=1S/C19H20F3N5O/c20-19(21,22)14-10-23-18(27-17(14)24-12-4-2-5-12)25-13-7-8-15-11(9-13)3-1-6-16(28)26-15/h7-10,12H,1-6H2,(H,26,28)(H2,23,24,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of GST-tagged pyk2 (unknown origin) assessed as inhibition of poly-Glu-Tyr phosphorylation				Bioorg Med Chem Lett 18: 6071-7 (2008) Article DOI: 10.1016/j.bmcl.2008.10.030 BindingDB Entry DOI: 10.7270/Q2C8295H
					More data for this Ligand-Target Pair