BDBM50246273 (R)-2-(3-(2-amino-2-oxoethyl)-4,6-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-yl)acetamide::CHEMBL487068

SMILES: CN1C(=O)NC(=O)[C@]11Cc2ccc(NC(=O)Cn3c4cc(C)cc(C)c4n(CC(N)=O)c3=O)cc2C1

InChI Key: InChIKey=YDCLRNYEDRVZTL-RUZDIDTESA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50246273   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50246273 ((R)-2-(3-(2-amino-2-oxoethyl)-4,6-dimethyl-2-oxo-2...) Show SMILES CN1C(=O)NC(=O)[C@]11Cc2ccc(NC(=O)Cn3c4cc(C)cc(C)c4n(CC(N)=O)c3=O)cc2C1 |r| Show InChI InChI=1S/C25H26N6O5/c1-13-6-14(2)21-18(7-13)30(24(36)31(21)11-19(26)32)12-20(33)27-17-5-4-15-9-25(10-16(15)8-17)22(34)28-23(35)29(25)3/h4-8H,9-12H2,1-3H3,(H2,26,32)(H,27,33)(H,28,34,35)/t25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cells				Bioorg Med Chem Lett 18: 6122-5 (2008) Article DOI: 10.1016/j.bmcl.2008.10.019 BindingDB Entry DOI: 10.7270/Q24Q7TTF
					More data for this Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50246273 ((R)-2-(3-(2-amino-2-oxoethyl)-4,6-dimethyl-2-oxo-2...) Show SMILES CN1C(=O)NC(=O)[C@]11Cc2ccc(NC(=O)Cn3c4cc(C)cc(C)c4n(CC(N)=O)c3=O)cc2C1 |r| Show InChI InChI=1S/C25H26N6O5/c1-13-6-14(2)21-18(7-13)30(24(36)31(21)11-19(26)32)12-20(33)27-17-5-4-15-9-25(10-16(15)8-17)22(34)28-23(35)29(25)3/h4-8H,9-12H2,1-3H3,(H2,26,32)(H,27,33)(H,28,34,35)/t25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production				Bioorg Med Chem Lett 18: 6122-5 (2008) Article DOI: 10.1016/j.bmcl.2008.10.019 BindingDB Entry DOI: 10.7270/Q24Q7TTF
					More data for this Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM50246273 ((R)-2-(3-(2-amino-2-oxoethyl)-4,6-dimethyl-2-oxo-2...) Show SMILES CN1C(=O)NC(=O)[C@]11Cc2ccc(NC(=O)Cn3c4cc(C)cc(C)c4n(CC(N)=O)c3=O)cc2C1 |r| Show InChI InChI=1S/C25H26N6O5/c1-13-6-14(2)21-18(7-13)30(24(36)31(21)11-19(26)32)12-20(33)27-17-5-4-15-9-25(10-16(15)8-17)22(34)28-23(35)29(25)3/h4-8H,9-12H2,1-3H3,(H2,26,32)(H,27,33)(H,28,34,35)/t25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of...				Bioorg Med Chem Lett 18: 6122-5 (2008) Article DOI: 10.1016/j.bmcl.2008.10.019 BindingDB Entry DOI: 10.7270/Q24Q7TTF
					More data for this Ligand-Target Pair