BDBM50246458 4-(2-(6-methoxy-3,4-dihydro-2H-chromen-3-yl)-3H-benzo[d]imidazol-5-yl)pyrimidin-2-amine::4-(2-(6-methoxychroman-3-yl)-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine::CHEMBL454638

SMILES: COc1ccc2OCC(Cc2c1)c1nc2cc(ccc2[nH]1)-c1ccnc(N)n1

InChI Key: InChIKey=WEEWAVMLLVLCNC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50246458   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50246458 (4-(2-(6-methoxy-3,4-dihydro-2H-chromen-3-yl)-3H-be...) Show SMILES COc1ccc2OCC(Cc2c1)c1nc2cc(ccc2[nH]1)-c1ccnc(N)n1 Show InChI InChI=1S/C21H19N5O2/c1-27-15-3-5-19-13(9-15)8-14(11-28-19)20-24-17-4-2-12(10-18(17)25-20)16-6-7-23-21(22)26-16/h2-7,9-10,14H,8,11H2,1H3,(H,24,25)(H2,22,23,26)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	99	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Florida Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				Bioorg Med Chem Lett 18: 6390-3 (2008) Article DOI: 10.1016/j.bmcl.2008.10.095 BindingDB Entry DOI: 10.7270/Q2T43SX6
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50246458 (4-(2-(6-methoxy-3,4-dihydro-2H-chromen-3-yl)-3H-be...) Show SMILES COc1ccc2OCC(Cc2c1)c1nc2cc(ccc2[nH]1)-c1ccnc(N)n1 Show InChI InChI=1S/C21H19N5O2/c1-27-15-3-5-19-13(9-15)8-14(11-28-19)20-24-17-4-2-12(10-18(17)25-20)16-6-7-23-21(22)26-16/h2-7,9-10,14H,8,11H2,1H3,(H,24,25)(H2,22,23,26)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Florida Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin)				Bioorg Med Chem Lett 18: 6390-3 (2008) Article DOI: 10.1016/j.bmcl.2008.10.095 BindingDB Entry DOI: 10.7270/Q2T43SX6
					More data for this Ligand-Target Pair