BindingDB PrimarySearch

BDBM50246461 4-(7-fluoro-2-(6-methoxy-3,4-dihydro-2H-chromen-3-yl)-3H-benzo[d]imidazol-5-yl)pyrimidin-2-amine::CHEMBL452598

SMILES: COc1ccc2OCC(Cc2c1)c1nc2cc(cc(F)c2[nH]1)-c1ccnc(N)n1

InChI Key: InChIKey=LGNRWEUQQPIDQM-UHFFFAOYSA-N

Data: 5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50246461
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50246461 (4-(7-fluoro-2-(6-methoxy-3,4-dihydro-2H-chromen-3-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	<6	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Florida Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				Bioorg Med Chem Lett 18: 6390-3 (2008) Article DOI: 10.1016/j.bmcl.2008.10.095 BindingDB Entry DOI: 10.7270/Q2T43SX6
The Scripps Research Institute Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50246461 (4-(7-fluoro-2-(6-methoxy-3,4-dihydro-2H-chromen-3-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Florida Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin)				Bioorg Med Chem Lett 18: 6390-3 (2008) Article DOI: 10.1016/j.bmcl.2008.10.095 BindingDB Entry DOI: 10.7270/Q2T43SX6
The Scripps Research Institute Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM50246461 (4-(7-fluoro-2-(6-methoxy-3,4-dihydro-2H-chromen-3-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.68E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Florida Curated by ChEMBL					Assay Description Inhibition of JNK3				Bioorg Med Chem Lett 18: 6390-3 (2008) Article DOI: 10.1016/j.bmcl.2008.10.095 BindingDB Entry DOI: 10.7270/Q2T43SX6
The Scripps Research Institute Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM50246461 (4-(7-fluoro-2-(6-methoxy-3,4-dihydro-2H-chromen-3-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.41E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Florida Curated by ChEMBL					Assay Description Inhibition of JNK1				Bioorg Med Chem Lett 18: 6390-3 (2008) Article DOI: 10.1016/j.bmcl.2008.10.095 BindingDB Entry DOI: 10.7270/Q2T43SX6
The Scripps Research Institute Florida Curated by ChEMBL					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50246461 (4-(7-fluoro-2-(6-methoxy-3,4-dihydro-2H-chromen-3-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Florida Curated by ChEMBL					Assay Description Inhibition of Akt1				Bioorg Med Chem Lett 18: 6390-3 (2008) Article DOI: 10.1016/j.bmcl.2008.10.095 BindingDB Entry DOI: 10.7270/Q2T43SX6
The Scripps Research Institute Florida Curated by ChEMBL					More data for this Ligand-Target Pair