BDBM50246540 (R)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2-(1-methoxypropan-2-yloxy)pyridin-3-yl)-2-(pyridin-2-ylmethyl)-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one::CHEMBL444157

SMILES: CCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)COC)c(c1)-c1nc2c(CC)n(Cc3ccccn3)nc2c(=O)[nH]1

InChI Key: InChIKey=AXJKWRLSLUKVML-LJQANCHMSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50246540   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Canis familiaris)	BDBM50246540 ((R)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2...) Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)COC)c(c1)-c1nc2c(CC)n(Cc3ccccn3)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C28H36N8O5S/c1-5-23-24-25(33-36(23)17-20-9-7-8-10-29-20)27(37)32-26(31-24)22-15-21(16-30-28(22)41-19(3)18-40-4)42(38,39)35-13-11-34(6-2)12-14-35/h7-10,15-16,19H,5-6,11-14,17-18H2,1-4H3,(H,31,32,37)/t19-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.54E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of canine retina PDE6 by scintillation proximity assay				Bioorg Med Chem Lett 18: 6033-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.037 BindingDB Entry DOI: 10.7270/Q2H131WT
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50246540 ((R)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2...) Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)COC)c(c1)-c1nc2c(CC)n(Cc3ccccn3)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C28H36N8O5S/c1-5-23-24-25(33-36(23)17-20-9-7-8-10-29-20)27(37)32-26(31-24)22-15-21(16-30-28(22)41-19(3)18-40-4)42(38,39)35-13-11-34(6-2)12-14-35/h7-10,15-16,19H,5-6,11-14,17-18H2,1-4H3,(H,31,32,37)/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.620	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human corpus cavernosum PDE5 by scintillation proximity assay				Bioorg Med Chem Lett 18: 6033-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.037 BindingDB Entry DOI: 10.7270/Q2H131WT
					More data for this Ligand-Target Pair