BDBM50246541 (R)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2-(1-methoxypropan-2-yloxy)pyridin-3-yl)-2-(2-methoxyethyl)-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one::CHEMBL514435

SMILES: CCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)COC)c(c1)-c1nc2c(CC)n(CCOC)nc2c(=O)[nH]1

InChI Key: InChIKey=ZAFPETYWHMLHGN-QGZVFWFLSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50246541   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Canis familiaris)	BDBM50246541 ((R)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2...) Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)COC)c(c1)-c1nc2c(CC)n(CCOC)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C25H37N7O6S/c1-6-20-21-22(29-32(20)12-13-36-4)24(33)28-23(27-21)19-14-18(15-26-25(19)38-17(3)16-37-5)39(34,35)31-10-8-30(7-2)9-11-31/h14-15,17H,6-13,16H2,1-5H3,(H,27,28,33)/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	734	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of canine retina PDE6 by scintillation proximity assay				Bioorg Med Chem Lett 18: 6033-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.037 BindingDB Entry DOI: 10.7270/Q2H131WT
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50246541 ((R)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2...) Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)COC)c(c1)-c1nc2c(CC)n(CCOC)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C25H37N7O6S/c1-6-20-21-22(29-32(20)12-13-36-4)24(33)28-23(27-21)19-14-18(15-26-25(19)38-17(3)16-37-5)39(34,35)31-10-8-30(7-2)9-11-31/h14-15,17H,6-13,16H2,1-5H3,(H,27,28,33)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.890	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human corpus cavernosum PDE5 by scintillation proximity assay				Bioorg Med Chem Lett 18: 6033-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.037 BindingDB Entry DOI: 10.7270/Q2H131WT
					More data for this Ligand-Target Pair