BDBM50246571 4-(4-hydroxyphenyl)-6,7-dimethoxy-2H-pyrido[3,4-b]indol-1(9H)-one::CHEMBL461162

SMILES: COc1cc2[nH]c3c(c(c[nH]c3=O)-c3ccc(O)cc3)c2cc1OC

InChI Key: InChIKey=MKOGRTXXHLJYQA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50246571   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50246571 (4-(4-hydroxyphenyl)-6,7-dimethoxy-2H-pyrido[3,4-b]...) Show SMILES COc1cc2[nH]c3c(c(c[nH]c3=O)-c3ccc(O)cc3)c2cc1OC Show InChI InChI=1S/C19H16N2O4/c1-24-15-7-12-14(8-16(15)25-2)21-18-17(12)13(9-20-19(18)23)10-3-5-11(22)6-4-10/h3-9,21-22H,1-2H3,(H,20,23)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Universita di Milano Curated by ChEMBL					Assay Description Inhibition of recombinant RET active protein (unknown origin) by immunoblotting				J Med Chem 51: 7777-87 (2008) Article DOI: 10.1021/jm8007823 BindingDB Entry DOI: 10.7270/Q2DN44X5
					More data for this Ligand-Target Pair