BDBM50246880 CHEMBL4088042
SMILES: FC(F)(F)c1cc(Oc2ccc(NS(=O)(=O)c3ccc(NC(=O)N4CCOCC4)cc3)cc2C#N)ccc1Cl
InChI Key: InChIKey=NCVCUVBVPPKJDO-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
LDL-associated phospholipase A2 (Homo sapiens (Human)) | BDBM50246880 (CHEMBL4088042) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
ShanghaiTech University Curated by ChEMBL | Assay Description Inhibition of human recombinant GST-tagged Lp-PLA2 (47 to 429 residues) expressed in Escherichia coli Rosetta(DE3) pLysS using 2-thio-PAF as substrat... | J Med Chem 60: 10231-10244 (2017) Article DOI: 10.1021/acs.jmedchem.7b01530 BindingDB Entry DOI: 10.7270/Q2959M00 | |||||||||||
More data for this Ligand-Target Pair |