null

SMILES: COC(C1CCOC1)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl

InChI Key: InChIKey=AZFROWZIMGUVBM-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50246927   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM50246927 (CHEMBL4060447 | US10570121, Example 127) Show SMILES COC(C1CCOC1)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl Show InChI InChI=1S/C23H26Cl2N2O5/c1-12-8-18(30-2)16(22(28)26-12)10-27-6-4-14-17(24)9-15(20(25)19(14)23(27)29)21(31-3)13-5-7-32-11-13/h8-9,13,21H,4-7,10-11H2,1-3H3,(H,26,28)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...				US Patent US10570121 (2020) BindingDB Entry DOI: 10.7270/Q28W3GQD
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM50246927 (CHEMBL4060447 | US10570121, Example 127) Show SMILES COC(C1CCOC1)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl Show InChI InChI=1S/C23H26Cl2N2O5/c1-12-8-18(30-2)16(22(28)26-12)10-27-6-4-14-17(24)9-15(20(25)19(14)23(27)29)21(31-3)13-5-7-32-11-13/h8-9,13,21H,4-7,10-11H2,1-3H3,(H,26,28)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...				US Patent US10570121 (2020) BindingDB Entry DOI: 10.7270/Q28W3GQD
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM50246927 (CHEMBL4060447 | US10570121, Example 127) Show SMILES COC(C1CCOC1)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl Show InChI InChI=1S/C23H26Cl2N2O5/c1-12-8-18(30-2)16(22(28)26-12)10-27-6-4-14-17(24)9-15(20(25)19(14)23(27)29)21(31-3)13-5-7-32-11-13/h8-9,13,21H,4-7,10-11H2,1-3H3,(H,26,28)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	56	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...				US Patent US10570121 (2020) BindingDB Entry DOI: 10.7270/Q28W3GQD
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM50246927 (CHEMBL4060447 | US10570121, Example 127) Show SMILES COC(C1CCOC1)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl Show InChI InChI=1S/C23H26Cl2N2O5/c1-12-8-18(30-2)16(22(28)26-12)10-27-6-4-14-17(24)9-15(20(25)19(14)23(27)29)21(31-3)13-5-7-32-11-13/h8-9,13,21H,4-7,10-11H2,1-3H3,(H,26,28)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	58	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...				US Patent US10570121 (2020) BindingDB Entry DOI: 10.7270/Q28W3GQD
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [2-746,Y641N] (Homo sapiens (Human))	BDBM50246927 (CHEMBL4060447 | US10570121, Example 127) Show SMILES COC(C1CCOC1)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl Show InChI InChI=1S/C23H26Cl2N2O5/c1-12-8-18(30-2)16(22(28)26-12)10-27-6-4-14-17(24)9-15(20(25)19(14)23(27)29)21(31-3)13-5-7-32-11-13/h8-9,13,21H,4-7,10-11H2,1-3H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...				US Patent US10570121 (2020) BindingDB Entry DOI: 10.7270/Q28W3GQD
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [2-746,Y641N] (Homo sapiens (Human))	BDBM50246927 (CHEMBL4060447 | US10570121, Example 127) Show SMILES COC(C1CCOC1)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl Show InChI InChI=1S/C23H26Cl2N2O5/c1-12-8-18(30-2)16(22(28)26-12)10-27-6-4-14-17(24)9-15(20(25)19(14)23(27)29)21(31-3)13-5-7-32-11-13/h8-9,13,21H,4-7,10-11H2,1-3H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...				US Patent US10570121 (2020) BindingDB Entry DOI: 10.7270/Q28W3GQD
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [2-746,Y641N] (Homo sapiens (Human))	BDBM50246927 (CHEMBL4060447 | US10570121, Example 127) Show SMILES COC(C1CCOC1)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl Show InChI InChI=1S/C23H26Cl2N2O5/c1-12-8-18(30-2)16(22(28)26-12)10-27-6-4-14-17(24)9-15(20(25)19(14)23(27)29)21(31-3)13-5-7-32-11-13/h8-9,13,21H,4-7,10-11H2,1-3H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	165	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...				US Patent US10570121 (2020) BindingDB Entry DOI: 10.7270/Q28W3GQD
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM50246927 (CHEMBL4060447 | US10570121, Example 127) Show SMILES COC(C1CCOC1)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl Show InChI InChI=1S/C23H26Cl2N2O5/c1-12-8-18(30-2)16(22(28)26-12)10-27-6-4-14-17(24)9-15(20(25)19(14)23(27)29)21(31-3)13-5-7-32-11-13/h8-9,13,21H,4-7,10-11H2,1-3H3,(H,26,28)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Curated by ChEMBL					Assay Description Inhibition of EZH2 in human KARPAS422 cells assessed as reduction in H3K27me3 level after 72 hrs by ELISA				J Med Chem 61: 650-665 (2018) Article DOI: 10.1021/acs.jmedchem.7b01375 BindingDB Entry DOI: 10.7270/Q2X069G8
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM50246927 (CHEMBL4060447 | US10570121, Example 127) Show SMILES COC(C1CCOC1)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl Show InChI InChI=1S/C23H26Cl2N2O5/c1-12-8-18(30-2)16(22(28)26-12)10-27-6-4-14-17(24)9-15(20(25)19(14)23(27)29)21(31-3)13-5-7-32-11-13/h8-9,13,21H,4-7,10-11H2,1-3H3,(H,26,28)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Curated by ChEMBL					Assay Description Inhibition of EZH2 in human KARPAS422 cells assessed as reduction in H3K27me3 level after 72 hrs by ELISA				J Med Chem 61: 650-665 (2018) Article DOI: 10.1021/acs.jmedchem.7b01375 BindingDB Entry DOI: 10.7270/Q2X069G8
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM50246927 (CHEMBL4060447 | US10570121, Example 127) Show SMILES COC(C1CCOC1)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl Show InChI InChI=1S/C23H26Cl2N2O5/c1-12-8-18(30-2)16(22(28)26-12)10-27-6-4-14-17(24)9-15(20(25)19(14)23(27)29)21(31-3)13-5-7-32-11-13/h8-9,13,21H,4-7,10-11H2,1-3H3,(H,26,28)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Curated by ChEMBL					Assay Description Inhibition of EZH2 in human KARPAS422 cells assessed as reduction in H3K27me3 level after 72 hrs by ELISA				J Med Chem 61: 650-665 (2018) Article DOI: 10.1021/acs.jmedchem.7b01375 BindingDB Entry DOI: 10.7270/Q2X069G8
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM50246927 (CHEMBL4060447 | US10570121, Example 127) Show SMILES COC(C1CCOC1)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl Show InChI InChI=1S/C23H26Cl2N2O5/c1-12-8-18(30-2)16(22(28)26-12)10-27-6-4-14-17(24)9-15(20(25)19(14)23(27)29)21(31-3)13-5-7-32-11-13/h8-9,13,21H,4-7,10-11H2,1-3H3,(H,26,28)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	391	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Curated by ChEMBL					Assay Description Inhibition of EZH2 in human KARPAS422 cells assessed as reduction in H3K27me3 level after 72 hrs by ELISA				J Med Chem 61: 650-665 (2018) Article DOI: 10.1021/acs.jmedchem.7b01375 BindingDB Entry DOI: 10.7270/Q2X069G8
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [2-746,Y641N] (Homo sapiens (Human))	BDBM50246927 (CHEMBL4060447 | US10570121, Example 127) Show SMILES COC(C1CCOC1)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl Show InChI InChI=1S/C23H26Cl2N2O5/c1-12-8-18(30-2)16(22(28)26-12)10-27-6-4-14-17(24)9-15(20(25)19(14)23(27)29)21(31-3)13-5-7-32-11-13/h8-9,13,21H,4-7,10-11H2,1-3H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	892	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...				US Patent US10570121 (2020) BindingDB Entry DOI: 10.7270/Q28W3GQD
					More data for this Ligand-Target Pair