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SMILES: Clc1ccc(CCCOCCCN2CCCCC2)cc1
InChI Key: InChIKey=NNACHAUCXXVJSP-UHFFFAOYSA-N
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd. Curated by ChEMBL | Assay Description Antagonist activity at human histamine H3 receptor expressed in HEK293 cells by [35S]gammaS binding assay | J Med Chem 52: 3855-68 (2009) Article DOI: 10.1021/jm900409x BindingDB Entry DOI: 10.7270/Q2SB46NQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at recombinant human H3 receptor expressed in CHO-K1 cell membranes incubated for 60 mins by [35S]GTPgammaS binding assay | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112667 BindingDB Entry DOI: 10.7270/Q2HD80BX | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (GUINEA PIG) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Palack£ University Curated by ChEMBL | Assay Description Inhibition of Guinea Pig Ileum H3R | Eur J Med Chem 181: (2019) Article DOI: 10.1016/j.ejmech.2019.111569 BindingDB Entry DOI: 10.7270/Q2H41VXG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (GUINEA PIG) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College Curated by ChEMBL | Assay Description Antagonist activity at human histamine H3 receptor expressed in HEK293 cells by [35S]GTPgammaS binding assay | Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (GUINEA PIG) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Palack£ University Curated by ChEMBL | Assay Description Inhibition of Guinea Pig Ileum H3R | Eur J Med Chem 181: (2019) Article DOI: 10.1016/j.ejmech.2019.111569 BindingDB Entry DOI: 10.7270/Q2H41VXG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to human H3R | Citation and Details Article DOI: 10.1016/j.ejmech.2020.113041 BindingDB Entry DOI: 10.7270/Q2MP570W | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College Curated by ChEMBL | Assay Description Inhibition of human H3 receptor | Eur J Med Chem 152: 223-234 (2018) Article DOI: 10.1016/j.ejmech.2018.04.043 BindingDB Entry DOI: 10.7270/Q2697632 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College Curated by ChEMBL | Assay Description Binding affinity to human histamine H3 receptor | Bioorg Med Chem 25: 2701-2712 (2017) Article DOI: 10.1016/j.bmc.2017.03.031 BindingDB Entry DOI: 10.7270/Q2833VPK | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.912 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity in Nluc-hH3R assessed in HEK293 cells by NanoBRET binding assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01089 BindingDB Entry DOI: 10.7270/Q2TB1BTS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College Curated by ChEMBL | Assay Description Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in CHO-K1 cells | Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at histamine H3 receptor (unknown origin) | Citation and Details Article DOI: 10.1016/j.bmc.2021.116462 BindingDB Entry DOI: 10.7270/Q2DR30DF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity in Nluc-hH3R assessed in HEK293T cells by NanoBRET binding assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01089 BindingDB Entry DOI: 10.7270/Q2TB1BTS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells | Eur J Med Chem 44: 4413-25 (2009) Article DOI: 10.1016/j.ejmech.2009.06.007 BindingDB Entry DOI: 10.7270/Q28S4Q7C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johann Wolfgang Goethe University Curated by ChEMBL | Assay Description Displacement of [125I]iodoproxyfan human histamine H3 receptor | Bioorg Med Chem Lett 20: 5879-82 (2010) Article DOI: 10.1016/j.bmcl.2010.07.098 BindingDB Entry DOI: 10.7270/Q2KH0NJ3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College Curated by ChEMBL | Assay Description Displacement of [125I]-iodoproxyfan from human striatal full length H3 receptor after 60 mins by gamma counting method | Bioorg Med Chem 26: 2573-2585 (2018) Article DOI: 10.1016/j.bmc.2018.04.023 BindingDB Entry DOI: 10.7270/Q2TQ641P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College Curated by ChEMBL | Assay Description Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in rat C6 cells | Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johann Wolfgang Goethe University Curated by ChEMBL | Assay Description Displacement of [125I]Iodoproxyfan from human histamine H3 receptor expressed in HEK293 cells | Bioorg Med Chem Lett 20: 5883-6 (2010) Article DOI: 10.1016/j.bmcl.2010.07.109 BindingDB Entry DOI: 10.7270/Q2BZ6678 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johann Wolfgang Goethe-Universität Curated by ChEMBL | Assay Description Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cells | Bioorg Med Chem Lett 19: 2172-5 (2009) Article DOI: 10.1016/j.bmcl.2009.02.110 BindingDB Entry DOI: 10.7270/Q2H41RBM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [3H]Nalpha-methylhistamine from recombinant human histamine H3 receptor stably transfected in HEK-293T cells membrane incubated for 9... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112150 BindingDB Entry DOI: 10.7270/Q2C53QGV | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Catania Curated by ChEMBL | Assay Description Displacement of [3H]N-alpha-Methylhistamine from human recombinant H3 receptor expressed in HEK293 cells by competitive binding assay | Eur J Med Chem 86: 578-88 (2014) Article DOI: 10.1016/j.ejmech.2014.09.011 BindingDB Entry DOI: 10.7270/Q2222WCC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
United Arab Emirates University Curated by ChEMBL | Assay Description Displacement of [3H]N-alpha-methylhistamine from human H3 receptor expressed in HEK-293 cell membrane after 90 mins by liquid scintillation counting ... | Eur J Med Chem 77: 269-79 (2014) Article DOI: 10.1016/j.ejmech.2014.03.014 BindingDB Entry DOI: 10.7270/Q29K4CR6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [3H]Nalpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK293 cells incubated for 90 mins by competitio... | Citation and Details Article DOI: 10.1016/j.bmc.2021.116462 BindingDB Entry DOI: 10.7270/Q2DR30DF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College Curated by ChEMBL | Assay Description Displacement of [3H]-N-alpha-methylhistamine from human recombinant full length H3R expressed in HEK293 cell membranes incubated for 90 mins by liqui... | Bioorg Med Chem 25: 5341-5354 (2017) Article DOI: 10.1016/j.bmc.2017.07.058 BindingDB Entry DOI: 10.7270/Q29W0K0D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [3H]N-alpha-Methylhistamine from recombinant human histamine H3 receptor expressed in human HEK293 cells incubated for 90 mins by mic... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112743 BindingDB Entry DOI: 10.7270/Q2P272S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College Curated by ChEMBL | Assay Description Displacement of [3H]-N-alpha-methylhistamine from human histamine H3 receptor stably expressed in HEK293 cell membrane after 90 mins | Eur J Med Chem 185: (2020) Article DOI: 10.1016/j.ejmech.2019.111785 BindingDB Entry DOI: 10.7270/Q2Q81HF9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Mus musculus) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College Curated by ChEMBL | Assay Description Displacement of [125I]-iodoproxyfan from mouse brain cortex H3 receptor after 60 mins by gamma counting method | Bioorg Med Chem 26: 2573-2585 (2018) Article DOI: 10.1016/j.bmc.2018.04.023 BindingDB Entry DOI: 10.7270/Q2TQ641P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 14.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College Curated by ChEMBL | Assay Description Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cells | Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Rattus norvegicus (rat)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College Curated by ChEMBL | Assay Description Displacement of [125I]-iodoproxyfan from rat brain cortex H3 receptor after 60 mins by gamma counting method | Bioorg Med Chem 26: 2573-2585 (2018) Article DOI: 10.1016/j.bmc.2018.04.023 BindingDB Entry DOI: 10.7270/Q2TQ641P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Rattus norvegicus (rat)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College Curated by ChEMBL | Assay Description Binding affinity to histamine H3 receptor in rat cerebral cortex | Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Rattus norvegicus (rat)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College Curated by ChEMBL | Assay Description Binding affinity to rat histamine H3 receptor | Bioorg Med Chem 25: 2701-2712 (2017) Article DOI: 10.1016/j.bmc.2017.03.031 BindingDB Entry DOI: 10.7270/Q2833VPK | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Rattus norvegicus (rat)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to rat H3R | Citation and Details Article DOI: 10.1016/j.ejmech.2020.113041 BindingDB Entry DOI: 10.7270/Q2MP570W | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd Curated by ChEMBL | Assay Description Displacement of [3]-RAMH from recombinant human histamine H3 receptor expressed in CHO-K1 cell membranes after 60 mins by scintillation counting | J Med Chem 62: 1203-1217 (2019) Article DOI: 10.1021/acs.jmedchem.8b01280 BindingDB Entry DOI: 10.7270/Q2XD152G | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in CHO-K1 cells by microbeta scintillation analysi... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112743 BindingDB Entry DOI: 10.7270/Q2P272S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H1 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
United Arab Emirates University Curated by ChEMBL | Assay Description Displacement of [3H]pyrilamine from human H1 receptor expressed in CHO cell membrane after 120 mins by liquid scintillation counting analysis | Eur J Med Chem 77: 269-79 (2014) Article DOI: 10.1016/j.ejmech.2014.03.014 BindingDB Entry DOI: 10.7270/Q29K4CR6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H4 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
United Arab Emirates University Curated by ChEMBL | Assay Description Displacement of [3H]histamine from human H4 receptor expressed in Sf9 cell membrane co-transfected with Galphai2 and Gbeta1gamma2 after 60 mins by li... | Eur J Med Chem 77: 269-79 (2014) Article DOI: 10.1016/j.ejmech.2014.03.014 BindingDB Entry DOI: 10.7270/Q29K4CR6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H4 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College Curated by ChEMBL | Assay Description Inhibition of human H4 receptor | Eur J Med Chem 152: 223-234 (2018) Article DOI: 10.1016/j.ejmech.2018.04.043 BindingDB Entry DOI: 10.7270/Q2697632 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H4 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to human H4R | Citation and Details Article DOI: 10.1016/j.ejmech.2020.113041 BindingDB Entry DOI: 10.7270/Q2MP570W | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College Curated by ChEMBL | Assay Description Inhibition of human ERG expressed in CHO cells at holding potential of -90 mV by patch clamp method | Bioorg Med Chem 25: 5341-5354 (2017) Article DOI: 10.1016/j.bmc.2017.07.058 BindingDB Entry DOI: 10.7270/Q29W0K0D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cholinesterase (Equus caballus (Horse)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College Curated by ChEMBL | Assay Description Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured... | Eur J Med Chem 185: (2020) Article DOI: 10.1016/j.ejmech.2019.111785 BindingDB Entry DOI: 10.7270/Q2Q81HF9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cholinesterase (Equus caballus (Horse)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of equine serum BChE using BTCI as substrate incubated for 5 mins followed by substrate addition and measured after 5 mins by spectrophoto... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112743 BindingDB Entry DOI: 10.7270/Q2P272S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (GUINEA PIG) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 5.62 | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College Curated by ChEMBL | Assay Description Antagonist activity at histamine H3 receptor in isolated guinea pig ileum | Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (GUINEA PIG) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College Curated by ChEMBL | Assay Description Antagonist activity at human histamine H3 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay | Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H3 receptor (Homo sapiens (Human)) | BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT... | J Med Chem 51: 6889-901 (2008) Article DOI: 10.1021/jm800569w BindingDB Entry DOI: 10.7270/Q27P8Z60 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
