BDBM50247395 8-Isopropyl-9-oxo-8,9-dihydro-thiazolo[5,4-f]quinazoline-2-carboximidic acid ethyl ester::CHEMBL510863

SMILES: CCOC(=N)c1nc2ccc3ncn(C(C)C)c(=O)c3c2s1

InChI Key: InChIKey=BVEVXRDDVGYLHG-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50247395   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 1 (Homo sapiens (Human))	BDBM50247395 (8-Isopropyl-9-oxo-8,9-dihydro-thiazolo[5,4-f]quina...) Show SMILES CCOC(=N)c1nc2ccc3ncn(C(C)C)c(=O)c3c2s1 Show InChI InChI=1S/C15H16N4O2S/c1-4-21-13(16)14-18-10-6-5-9-11(12(10)22-14)15(20)19(7-17-9)8(2)3/h5-8,16H,4H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Université de Nantes Curated by ChEMBL					Assay Description Inhibition of CDK1/cyclinB (unknown origin)				Eur J Med Chem 43: 1469-77 (2008) Article DOI: 10.1016/j.ejmech.2007.09.020 BindingDB Entry DOI: 10.7270/Q24M9495
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Homo sapiens (Human))	BDBM50247395 (8-Isopropyl-9-oxo-8,9-dihydro-thiazolo[5,4-f]quina...) Show SMILES CCOC(=N)c1nc2ccc3ncn(C(C)C)c(=O)c3c2s1 Show InChI InChI=1S/C15H16N4O2S/c1-4-21-13(16)14-18-10-6-5-9-11(12(10)22-14)15(20)19(7-17-9)8(2)3/h5-8,16H,4H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Université de Nantes Curated by ChEMBL					Assay Description Inhibition of CDK1 (unknown origin)				Eur J Med Chem 43: 1469-77 (2008) Article DOI: 10.1016/j.ejmech.2007.09.020 BindingDB Entry DOI: 10.7270/Q24M9495
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50247395 (8-Isopropyl-9-oxo-8,9-dihydro-thiazolo[5,4-f]quina...) Show SMILES CCOC(=N)c1nc2ccc3ncn(C(C)C)c(=O)c3c2s1 Show InChI InChI=1S/C15H16N4O2S/c1-4-21-13(16)14-18-10-6-5-9-11(12(10)22-14)15(20)19(7-17-9)8(2)3/h5-8,16H,4H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Université de Nantes Curated by ChEMBL					Assay Description Inhibition of GSK3alpha/beta (unknown origin)				Eur J Med Chem 43: 1469-77 (2008) Article DOI: 10.1016/j.ejmech.2007.09.020 BindingDB Entry DOI: 10.7270/Q24M9495
					More data for this Ligand-Target Pair
Cyclin-dependent-like kinase 5 (Homo sapiens (Human))	BDBM50247395 (8-Isopropyl-9-oxo-8,9-dihydro-thiazolo[5,4-f]quina...) Show SMILES CCOC(=N)c1nc2ccc3ncn(C(C)C)c(=O)c3c2s1 Show InChI InChI=1S/C15H16N4O2S/c1-4-21-13(16)14-18-10-6-5-9-11(12(10)22-14)15(20)19(7-17-9)8(2)3/h5-8,16H,4H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Université de Nantes Curated by ChEMBL					Assay Description Inhibition of CDK5/p25 (unknown origin)				Eur J Med Chem 43: 1469-77 (2008) Article DOI: 10.1016/j.ejmech.2007.09.020 BindingDB Entry DOI: 10.7270/Q24M9495
					More data for this Ligand-Target Pair