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BDBM50247533 CHEMBL4080109

SMILES: Cc1nc(-c2cnn(C)c2-c2ccc(cc2)C(F)(F)F)c2c(N)ncnn12

InChI Key: InChIKey=FNCRRUPTIYSVPT-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50247533   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))		BDBM50247533
PNG
(CHEMBL4080109)
Show SMILES Cc1nc(-c2cnn(C)c2-c2ccc(cc2)C(F)(F)F)c2c(N)ncnn12
Show InChI InChI=1S/C17H14F3N7/c1-9-25-13(15-16(21)22-8-24-27(9)15)12-7-23-26(2)14(12)10-3-5-11(6-4-10)17(18,19)20/h3-8H,1-2H3,(H2,21,22,24)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPA

J Med Chem 61: 1001-1018 (2018)


BindingDB Entry DOI: 10.7270/Q2ZS2ZZ4
More data for this
Ligand-Target Pair