BDBM50248051 CHEMBL448276::N-(3-fluoro-4-(2-(4-(piperazin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide

SMILES: Fc1cc(NC(=O)N2CCN(C2=O)c2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1ccc(CN2CCNCC2)cc1

InChI Key: InChIKey=KPPTZOUOPSHOGH-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50248051   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50248051 (CHEMBL448276 | N-(3-fluoro-4-(2-(4-(piperazin-1-yl...) Show SMILES Fc1cc(NC(=O)N2CCN(C2=O)c2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1ccc(CN2CCNCC2)cc1 Show InChI InChI=1S/C34H31FN6O3S/c35-27-20-25(38-33(42)41-19-18-40(34(41)43)26-4-2-1-3-5-26)10-11-29(27)44-30-12-13-37-28-21-31(45-32(28)30)24-8-6-23(7-9-24)22-39-16-14-36-15-17-39/h1-13,20-21,36H,14-19,22H2,(H,38,42)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins...				Bioorg Med Chem Lett 19: 1323-8 (2009) Article DOI: 10.1016/j.bmcl.2009.01.068 BindingDB Entry DOI: 10.7270/Q23F4PHJ
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50248051 (CHEMBL448276 | N-(3-fluoro-4-(2-(4-(piperazin-1-yl...) Show SMILES Fc1cc(NC(=O)N2CCN(C2=O)c2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1ccc(CN2CCNCC2)cc1 Show InChI InChI=1S/C34H31FN6O3S/c35-27-20-25(38-33(42)41-19-18-40(34(41)43)26-4-2-1-3-5-26)10-11-29(27)44-30-12-13-37-28-21-31(45-32(28)30)24-8-6-23(7-9-24)22-39-16-14-36-15-17-39/h1-13,20-21,36H,14-19,22H2,(H,38,42)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human c-MET				Eur J Med Chem 46: 3675-80 (2011) Article DOI: 10.1016/j.ejmech.2011.05.031 BindingDB Entry DOI: 10.7270/Q2891676
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50248051 (CHEMBL448276 | N-(3-fluoro-4-(2-(4-(piperazin-1-yl...) Show SMILES Fc1cc(NC(=O)N2CCN(C2=O)c2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1ccc(CN2CCNCC2)cc1 Show InChI InChI=1S/C34H31FN6O3S/c35-27-20-25(38-33(42)41-19-18-40(34(41)43)26-4-2-1-3-5-26)10-11-29(27)44-30-12-13-37-28-21-31(45-32(28)30)24-8-6-23(7-9-24)22-39-16-14-36-15-17-39/h1-13,20-21,36H,14-19,22H2,(H,38,42)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA				Bioorg Med Chem Lett 19: 1323-8 (2009) Article DOI: 10.1016/j.bmcl.2009.01.068 BindingDB Entry DOI: 10.7270/Q23F4PHJ
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50248051 (CHEMBL448276 | N-(3-fluoro-4-(2-(4-(piperazin-1-yl...) Show SMILES Fc1cc(NC(=O)N2CCN(C2=O)c2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1ccc(CN2CCNCC2)cc1 Show InChI InChI=1S/C34H31FN6O3S/c35-27-20-25(38-33(42)41-19-18-40(34(41)43)26-4-2-1-3-5-26)10-11-29(27)44-30-12-13-37-28-21-31(45-32(28)30)24-8-6-23(7-9-24)22-39-16-14-36-15-17-39/h1-13,20-21,36H,14-19,22H2,(H,38,42)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay				Bioorg Med Chem Lett 19: 1323-8 (2009) Article DOI: 10.1016/j.bmcl.2009.01.068 BindingDB Entry DOI: 10.7270/Q23F4PHJ
					More data for this Ligand-Target Pair