BDBM50248310 (R)-1-(4-tert-butylphenylsulfonyl)-2-methyl-4-(3-(pyridin-4-yl)propyl)piperazine::CHEMBL473954

SMILES: C[C@@H]1CN(CCCc2ccncc2)CCN1S(=O)(=O)c1ccc(cc1)C(C)(C)C

InChI Key: InChIKey=COUWYGSTDBDLQS-LJQANCHMSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50248310   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50248310 ((R)-1-(4-tert-butylphenylsulfonyl)-2-methyl-4-(3-(...) Show SMILES C[C@@H]1CN(CCCc2ccncc2)CCN1S(=O)(=O)c1ccc(cc1)C(C)(C)C |r| Show InChI InChI=1S/C23H33N3O2S/c1-19-18-25(15-5-6-20-11-13-24-14-12-20)16-17-26(19)29(27,28)22-9-7-21(8-10-22)23(2,3)4/h7-14,19H,5-6,15-18H2,1-4H3/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of full length human recombinant 11beta-HSD1 expressed in baculovirus insect cell system assessed as conversion of [3H]cortisone to [3H]co...				Bioorg Med Chem Lett 19: 1522-7 (2009) Article DOI: 10.1016/j.bmcl.2008.12.114 BindingDB Entry DOI: 10.7270/Q2QC03BN
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50248310 ((R)-1-(4-tert-butylphenylsulfonyl)-2-methyl-4-(3-(...) Show SMILES C[C@@H]1CN(CCCc2ccncc2)CCN1S(=O)(=O)c1ccc(cc1)C(C)(C)C |r| Show InChI InChI=1S/C23H33N3O2S/c1-19-18-25(15-5-6-20-11-13-24-14-12-20)16-17-26(19)29(27,28)22-9-7-21(8-10-22)23(2,3)4/h7-14,19H,5-6,15-18H2,1-4H3/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of full length human recombinant 11beta-HSD1 expressed in HEK293 cells in absence of NADPH				Bioorg Med Chem Lett 19: 1522-7 (2009) Article DOI: 10.1016/j.bmcl.2008.12.114 BindingDB Entry DOI: 10.7270/Q2QC03BN
					More data for this Ligand-Target Pair