BDBM50248470 2-(4-((R)-4-(2,2-difluoro-2-(pyridin-3-yl)ethyl)-2-methylpiperazin-1-ylsulfonyl)phenyl)-1,1,1-trifluoropropan-2-ol::CHEMBL490953

SMILES: C[C@@H]1CN(CC(F)(F)c2cccnc2)CCN1S(=O)(=O)c1ccc(cc1)C(C)(O)C(F)(F)F

InChI Key: InChIKey=BCKFFQISRMBMLR-NYRJJRHWSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50248470   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50248470 (2-(4-((R)-4-(2,2-difluoro-2-(pyridin-3-yl)ethyl)-2...) Show SMILES C[C@@H]1CN(CC(F)(F)c2cccnc2)CCN1S(=O)(=O)c1ccc(cc1)C(C)(O)C(F)(F)F |r| Show InChI InChI=1S/C21H24F5N3O3S/c1-15-13-28(14-20(22,23)17-4-3-9-27-12-17)10-11-29(15)33(31,32)18-7-5-16(6-8-18)19(2,30)21(24,25)26/h3-9,12,15,30H,10-11,13-14H2,1-2H3/t15-,19?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of full length human recombinant 11beta-HSD1 expressed in baculovirus insect cell system assessed as conversion of [3H]cortisone to [3H]co...				Bioorg Med Chem Lett 19: 1522-7 (2009) Article DOI: 10.1016/j.bmcl.2008.12.114 BindingDB Entry DOI: 10.7270/Q2QC03BN
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50248470 (2-(4-((R)-4-(2,2-difluoro-2-(pyridin-3-yl)ethyl)-2...) Show SMILES C[C@@H]1CN(CC(F)(F)c2cccnc2)CCN1S(=O)(=O)c1ccc(cc1)C(C)(O)C(F)(F)F |r| Show InChI InChI=1S/C21H24F5N3O3S/c1-15-13-28(14-20(22,23)17-4-3-9-27-12-17)10-11-29(15)33(31,32)18-7-5-16(6-8-18)19(2,30)21(24,25)26/h3-9,12,15,30H,10-11,13-14H2,1-2H3/t15-,19?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of full length human recombinant 11beta-HSD1 expressed in HEK293 cells in absence of NADPH				Bioorg Med Chem Lett 19: 1522-7 (2009) Article DOI: 10.1016/j.bmcl.2008.12.114 BindingDB Entry DOI: 10.7270/Q2QC03BN
					More data for this Ligand-Target Pair