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BDBM50248603 (3',5'-dichloro-2,6-dimethoxybiphenyl-4-yl)(phenyl)methanol::CHEMBL460544::US9139546, 15

SMILES: COc1cc(cc(OC)c1-c1cc(Cl)cc(Cl)c1)C(O)c1ccccc1

InChI Key: InChIKey=WGEMJULJOYKTBN-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50248603   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50248603
PNG
((3',5'-dichloro-2,6-dimethoxybiphenyl-4-yl)(phenyl...)
Show SMILES COc1cc(cc(OC)c1-c1cc(Cl)cc(Cl)c1)C(O)c1ccccc1
Show InChI InChI=1S/C21H18Cl2O3/c1-25-18-10-15(21(24)13-6-4-3-5-7-13)11-19(26-2)20(18)14-8-16(22)12-17(23)9-14/h3-12,21,24H,1-2H3
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US Patent
1.66 -12.2n/an/an/an/an/an/a30



The University of Tennessee Research Foundation

US Patent


Assay Description
Cell membranes from HEK293 cells transfected with the human CB1 receptor and membranes from CHO-K1 cells transfected with the human CB2 receptor were...


US Patent US9139546 (2015)


BindingDB Entry DOI: 10.7270/Q2TQ609M
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50248603
PNG
((3',5'-dichloro-2,6-dimethoxybiphenyl-4-yl)(phenyl...)
Show SMILES COc1cc(cc(OC)c1-c1cc(Cl)cc(Cl)c1)C(O)c1ccccc1
Show InChI InChI=1S/C21H18Cl2O3/c1-25-18-10-15(21(24)13-6-4-3-5-7-13)11-19(26-2)20(18)14-8-16(22)12-17(23)9-14/h3-12,21,24H,1-2H3
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Article
PubMed
1.66n/an/an/an/an/an/an/an/a



University of Tennessee-Memphis

Curated by ChEMBL


Assay Description
Binding affinity to human CB2 receptor transfected in HEK293 cells


Bioorg Med Chem Lett 19: 1691-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.100
BindingDB Entry DOI: 10.7270/Q2SX6D3N
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50248603
PNG
((3',5'-dichloro-2,6-dimethoxybiphenyl-4-yl)(phenyl...)
Show SMILES COc1cc(cc(OC)c1-c1cc(Cl)cc(Cl)c1)C(O)c1ccccc1
Show InChI InChI=1S/C21H18Cl2O3/c1-25-18-10-15(21(24)13-6-4-3-5-7-13)11-19(26-2)20(18)14-8-16(22)12-17(23)9-14/h3-12,21,24H,1-2H3
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Article
PubMed
>1.00E+3n/an/an/an/an/an/an/an/a



University of Tennessee-Memphis

Curated by ChEMBL


Assay Description
Binding affinity to human CB1 receptor transfected in HEK293 cells


Bioorg Med Chem Lett 19: 1691-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.100
BindingDB Entry DOI: 10.7270/Q2SX6D3N
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50248603
PNG
((3',5'-dichloro-2,6-dimethoxybiphenyl-4-yl)(phenyl...)
Show SMILES COc1cc(cc(OC)c1-c1cc(Cl)cc(Cl)c1)C(O)c1ccccc1
Show InChI InChI=1S/C21H18Cl2O3/c1-25-18-10-15(21(24)13-6-4-3-5-7-13)11-19(26-2)20(18)14-8-16(22)12-17(23)9-14/h3-12,21,24H,1-2H3
PDB

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Reactome pathway
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UniChem

Patents

US Patent
>1.00E+3>-8.32n/an/an/an/an/an/a30



The University of Tennessee Research Foundation

US Patent


Assay Description
Cell membranes from HEK293 cells transfected with the human CB1 receptor and membranes from CHO-K1 cells transfected with the human CB2 receptor were...


US Patent US9139546 (2015)


BindingDB Entry DOI: 10.7270/Q2TQ609M
More data for this
Ligand-Target Pair